Muehrcke's nails

Muehrcke's lines

Muehrcke's nails,^[1] Muehrcke's lines, or leukonychia striata, are changes in the fingernail that may be a sign of an underlying medical disorder or condition. Muehrcke's lines are white lines (leukonychia) that extend all the way across the nail and lie parallel to the lunula (half moon). In contrast to Beau's lines, they are not grooved. The lines are actually in the vascular nail bed underneath the nail plate, and as such, they do not move with nail growth. Meuhrcke's lines disappear when pressure is placed over the nail, blanching the underlying nail bed.

The appearance of Muehrcke's lines is nonspecific, but they are often associated with decreased protein synthesis, which may occur during periods of metabolic stress (e.g., after chemotherapy) and in hypoalbuminemic states such as the nephrotic syndrome.^{[2]:659[3][4]}

An example of Muehrcke's lines in the context of chemotherapy was published in the New England Journal of Medicine in 2007. ^[5]

Muehrcke's lines were described by Robert C. Muehrcke in 1956.^[6]

See also

• Half and half nails
• List of cutaneous conditions
• Mees' lines

References

1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
2. ^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0071380760.
3. ^ Bianchi L, Iraci S, Tomassoli M, Carrozzo AM, Nini G (1992). "Coexistence of apparent transverse leukonychia (Muehrcke's lines type) and longitudinal melanonychia after 5-fluorouracil/adriamycin/cyclophosphamide chemotherapy". Dermatology (Basel) 185 (3): 216–7. PMID 1446089. 
4. ^ Chapman S, Cohen PR (April 1997). "Transverse leukonychia in patients receiving cancer chemotherapy". South. Med. J. 90 (4): 395–8. PMID 9114829. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0038-4348&volume=90&issue=4&spage=395. 
5. ^ Morrison-Bryant M, Gradon JD (2007). "Muehrcke's Lines.". N Engl J Med. 357 (9): 917. doi:10.1056/NEJMicm065055. PMID 17761595. 
6. ^ MUEHRCKE RC (June 1956). "The finger-nails in chronic hypoalbuminaemia; a new physical sign". Br Med J 1 (4979): 1327–8. PMC 1980060. PMID 13316143. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1980060. Retrieved 2009-04-30. 

Bibliography

• Fawcett, Robert S.; Sean Linford, and Daniel L. Stulberg (March 15, 2004). "Nail Abnormalities: Clues to Systemic Disease". American Family Physician 69 (6): 1417. PMID 15053406. http://www.aafp.org/afp/20040315/1417.html. 
• James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0721629210.

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