Nikolsky's sign

Nikolsky's sign

Nikolsky's sign is a clinical dermatological sign, named after the Russian physician Pyotr Nikolsky (1858–1940). The sign is positive when slight rubbing of the skin results in exfoliation of the outermost layer.[1][2][3][4]

Nikolsky's sign is almost always present in toxic epidermal necrolysis[5] and is associated with pemphigus vulgaris.[6] It is useful in differentiating between pemphigus vulgaris (where it is present or positive) and bullous pemphigoid (where it is absent)

See also

References

  1. ^ Moss C, Gupta E (September 1998). "The Nikolsky sign in staphylococcal scalded skin syndrome". Arch. Dis. Child. 79 (3): 290. doi:10.1136/adc.79.3.290. PMC 1717681. PMID 9875032. http://adc.bmj.com/cgi/pmidlookup?view=long&pmid=9875032. 
  2. ^ "eMedicine - Pemphigus Foliaceus : Article by Robert A Schwartz". http://www.emedicine.com/derm/topic318.htm. 
  3. ^ Nikolski PV. Materiali K.uchenigu o pemphigus foliaceus [doctoral thesis]. Kiev. 1896.
  4. ^ "MedilinePlus: Nikolsky’s sign". http://www.nlm.nih.gov/medlineplus/ency/article/003285.htm. 
  5. ^ PMID 17161178
  6. ^ Ma, O. Emergency Medicine Manual. McGraw Hill. 2004.
v · d · eEponymous medical signs for integumentary system
Skin
Nails

M: INT, SF, LCT

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noco(i/b/d/q/u/r/p/m/k/v/f)/cong/tumr(n/e/d), sysi/epon

proc, drug (D2/3/4/5/8/11)

M: SKA

anat/phys/devp

noco/cong/tumr, sysi/epon

proc, drug(D10)

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