Nikolsky's sign

Nikolsky's sign

Nikolsky's sign is a clinical dermatological sign, named after the Russian physician Pyotr Nikolsky (1858–1940). The sign is positive when slight rubbing of the skin results in exfoliation of the outermost layer.[1][2][3][4]

Nikolsky's sign is almost always present in toxic epidermal necrolysis[5] and is associated with pemphigus vulgaris.[6] It is useful in differentiating between pemphigus vulgaris (where it is present or positive) and bullous pemphigoid (where it is absent)

See also

References

  1. ^ Moss C, Gupta E (September 1998). "The Nikolsky sign in staphylococcal scalded skin syndrome". Arch. Dis. Child. 79 (3): 290. doi:10.1136/adc.79.3.290. PMC 1717681. PMID 9875032. http://adc.bmj.com/cgi/pmidlookup?view=long&pmid=9875032. 
  2. ^ "eMedicine - Pemphigus Foliaceus : Article by Robert A Schwartz". http://www.emedicine.com/derm/topic318.htm. 
  3. ^ Nikolski PV. Materiali K.uchenigu o pemphigus foliaceus [doctoral thesis]. Kiev. 1896.
  4. ^ "MedilinePlus: Nikolsky’s sign". http://www.nlm.nih.gov/medlineplus/ency/article/003285.htm. 
  5. ^ PMID 17161178
  6. ^ Ma, O. Emergency Medicine Manual. McGraw Hill. 2004.
v · d · eEponymous medical signs for integumentary system
Skin
Nails

M: INT, SF, LCT

anat/phys/devp

noco(i/b/d/q/u/r/p/m/k/v/f)/cong/tumr(n/e/d), sysi/epon

proc, drug (D2/3/4/5/8/11)

M: SKA

anat/phys/devp

noco/cong/tumr, sysi/epon

proc, drug(D10)

Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • Nikolsky — Nikolsky, also spelled Nikolski (Russian: Никольский; masculine), or Nikolskaya (Никольская; feminine), is a Russian last name and name of other entities. Its neuter form is Nikolskoye (Никольское). People Alexander Nikolsky (1884–1953), Soviet… …   Wikipedia

  • Nikolsky sign — Ni·kol·sky sign (nĭ kolґske) [Petr Vasilyevich Nikolsky, Russian dermatologist, 1858–1940] see under sign …   Medical dictionary

  • Nikolsky sign — ready separation of the outer layer of the epidermis from the basal layer with sloughing of the skin produced by minor trauma such as a sliding or rubbing pressure on the skin; this may occur in pemphigus, certain hereditary blistering skin… …   Medical dictionary

  • Sign — Any abnormality that indicates a disease process, such as a change in appearance, sensation, or function, that is observed by a physician when evaluating a patient. * * * 1. Any abnormality indicative of disease, discoverable on examination of… …   Medical dictionary

  • Nikolsky — Pyotr V., Russian dermatologist, 1858–1940. See N. sign …   Medical dictionary

  • Asboe–Hansen sign — The Asboe Hansen sign (also known as indirect Nikolsky sign [1] or Nikolsky II sign [1]) refers to the extension of a blister to adjacent unblistered skin when pressure is put on the top of the bulla.[2] See also Nikolsky s sign List of cutaneous …   Wikipedia

  • Crowe sign — The Crowe sign or Crowe s sign is the presence of axillary (armpit) freckling in people with neurofibromatosis type I (von Recklinghausen s disease). These freckles occur in up to 30% of people with the disease and their presence is one of seven… …   Wikipedia

  • Darier's sign — is a change observed after stroking the skin of a person with systemic mastocytosis or urticaria pigmentosa. In general, the skin becomes swollen, itchy and red. This is a result of compression of mast cells, which are hyperactive in these… …   Wikipedia

  • Cicatricial pemphigoid — Classification and external resources ICD 10 L12.1 ICD 9 694.6 …   Wikipedia

  • Muehrcke's nails — Muehrcke s lines Muehrcke s nails,[1] Muehrcke s lines, or leukonychia striata, are changes in the fingernail that may be a sign of an underlying medical disorder or condition. Muehrcke s lines are white lines (leukonychia) that extend all the… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”