Uterine clear cell carcinoma

Uterine clear cell carcinoma
Uterine clear cell carcinoma
Classification and external resources
ICD-10 C54.1
ICD-9 182

Uterine clear cell carcinoma (CC) is a rare form of endometrial cancer with distinct morphological features on pathology; it is aggressive and has high recurrence rate. Like uterine papillary serous carcinoma CC does not develop from endometrial hyperplasia and is not hormone sensitive, rather it arises from an atrophic endometrium. Such lesions belong to the type II endometrial cancers.[1]



The lesion is found in patients who present typically with abnormal or postmenopausal bleeding. Such bleeding is followed by further evaluation leading to a tissue diagnosis, usually done by a dilatation and curettage (D&C). A work-up to follow would look for metastasis using imaging technology including sonography and MRI. The median age at diagnosis in a large study was 66 years.[2] Histologically the lesion may coexist with classical endometrial cancer.

Prognosis and treatment

Prognosis of the CC is affected by age, stage, and histology as well as treatment

The primary treatment is surgical. FIGO-cancer staging is done at the time of surgery which consists of peritoneal cytology, total hysterectomy, bilateral salpingo-oophorectomy, pelvic/para-aortic lymphadenectomy, and omentectomy. The tumor is aggressive and spreads quickly into the myometrium and the lymphatic system. Thus even in presumed early stages, lymphadenectomy and omentectomy should be included in the surgical approach. If the tumor has spread surgery is cytoreductive followed by radiation therapy and/or chemotherapy.[2][3]

The five years survival was reported to be 68%.[2]


UPSC is staged like other forms of endometrial carcinoma at time of surgery using the FIGO cancer staging system.

  • Stage IA: tumor is limited to the endometrium
  • Stage IB: invasion of less than half the myometrium
  • Stage IC: invasion of more than half the myometrium
  • Stage IIA: endocervical glandular involvement only
  • Stage IIB: cervical stromal invasion
  • Stage IIIA: tumor invades serosa or adnexa, or malignant peritoneal cytology
  • Stage IIIB: vaginal metastasis
  • Stage IIIC: metastasis to pelvic or para-aortic lymph nodes
  • Stage IVA: invasion of the bladder or bowel
  • Stage IVB: distant metastasis, including intraabdominal or inguinal lymph nodes


  1. ^ Gründker C, Günthert AR, Emons G. (2008). "Hormonal heterogeneity of endometrial cancer.". Adv Exp Med Biol. 2008;630:166-88. 630: 166–88. doi:10.1007/978-0-387-78818-0_11. PMID 18637491. 
  2. ^ a b c C A Hamilton, M K Cheung, K Osann, L Chen, N N Teng, T A Longacre, M A Powell, M R Hendrickson, D S Kapp and J K Chan. "Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers.". British Journal of Cancer (2006) 94, 642–646.. 
  3. ^ Stanojevic Z, Djordjevic B, Todorovska I, Lilic V, Zivadinovic R, Dunjic O. (2008). "Risk factors and adjuvant chemotherapy in the treatment of endometrial cancer.". J BUON. 2008 Jan-Mar;13(1):23-30. 13 (1): 23–30. PMID 18404782. 

Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Clear cell adenocarcinoma — Classification and external resources Micrograph of an ovarian clear cell adenocarinoma. H E stain …   Wikipedia

  • Clear cell adenocarcinoma of the vagina — Classification and external resources ICD O: 8310/3 DiseasesDB 2786 MeSH …   Wikipedia

  • Clear-cell ovarian carcinoma — Micrograph of an ovarian clear cell carcinoma. H E stain. Clear cell ovarian tumors are part of the surface epithelial stromal tumor group of ovarian cancers, accounting for 6% of these cancers. Clear cell tumors are also associated with the… …   Wikipedia

  • Clear-cell sarcoma of the kidney — Classification and external resources ICD O: 8964/3 Clear cell sarcoma of the kidney is a rare type of kidney cancer. Clear cell sarcoma can spread from the kidney to other organs, most commonly the bone, but also including the lungs, brain, and… …   Wikipedia

  • Squamous-cell carcinoma — Squamous cell carcinoma, NOS Classification and external resources SCC of the skin tends to arise from pre malignant lesions, actinic keratoses; surface is usually scaly and often ulcerates (as shown here). ICD 10 …   Wikipedia

  • Uterine cancer — Classification and external resources Malignant tumor of the uterus ICD 10 C54 ICD …   Wikipedia

  • Uterine fibroid — Uterine fibroids Classification and external resources Uterine Fibroids ICD 10 D25 …   Wikipedia

  • Small-cell carcinoma — Classification and external resources Micrograph of a small cell carcinoma of the lung showing cells with nuclear moulding, minimal amount of cytoplasm and stippled chromatin. FNA specim …   Wikipedia

  • carcinoma — Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell c.); the most commonly occurring kind of cancer. [G. karkinoma, fr. karkinos, cancer, + oma, tumor] Like other …   Medical dictionary

  • cell — cell1 cell like, adj. /sel/, n. 1. a small room, as in a convent or prison. 2. any of various small compartments or bounded areas forming part of a whole. 3. a small group acting as a unit within a larger organization: a local cell of the… …   Universalium

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”