Phenotypic trait

Phenotypic trait

A trait is a distinct variant of a phenotypic character of an organism that may be inherited, environmentally determined or be a combination of the two.[1] For example, eye color is a character or abstraction of an attribute, while blue, brown and hazel are traits.

Contents

Definition

A phenotypic trait is an obvious and observable trait; it is the expression of genes in an observable way. An example of a phenotypic trait is hair color, there are underlying genes that control the hair color, which make up the genotype, but the actual hair color, the part we see, is the phenotype. The phenotype is the physical characteristics of the organism. The phenotype is controlled by the genetic make-up of the organism and the environmental pressures the organism is subject to. [2]

A trait may be any single feature or quantifiable measurement of an organism. However, the most useful traits for genetic analysis are present in different forms in different individuals.

A visible trait is the final product of many molecular and biochemical processes. In most cases, information starts with DNA traveling to RNA and finally to protein (ultimately affecting organism structure and function). This is the central dogma of molecular biology as stated by Francis Crick.

This information flow may also be followed through the cell as it travels from the DNA in the nucleus, to the cytoplasm, to the ribosomes and the endoplasmic reticulum, and finally to the Golgi apparatus, which may package the final products for export outside the cell.

Cell products are released into the tissue, and organs of an organism, to finally affect the physiology in a way that produces a trait.

Genetic origin of traits in diploid organisms

The heritable unit that may influence a trait is called a gene. A gene is a portion of a chromosome. An important reference point along a chromosome, which is a very long and compacted string of DNA, is the centromere; the distance from a gene to the centromere is referred to as the gene's locus or map location. A chromosomal region known to control a trait while the responsible gene within not being identified is referred to as a quantitative trait locus.

The nucleus of a diploid cell contains two of each chromosome, with homologous (mostly identical) pairs of chromosomes having the same genes at the same loci.

Different phenotypic traits are caused by different forms of genes, or alleles, which arise by mutation in a single individual and are passed on to successive generations.

Mendelian expression of genes in diploid organisms

A gene is only a DNA code sequence; the slightly different variations of that sequence are called alleles. Alleles can be significantly different and produce different product RNAs.

Combinations of different alleles thus go on to generate different traits through the information flow charted above. For example, if the alleles on homologous chromosomes exhibit a "simple dominance" relationship, the trait of the "dominant" allele shows in the phenotype.

Gregor Mendel pioneered modern genetics. His most famous analyses were based on clear-cut traits with simple dominance. He determined that the heritable units, what he called "genes", occurred in pairs and could exhibit linkage. His tool was statistics: long before the molecular model of DNA was introduced by James D. Watson and Francis Crick.

He is also known to have 'cheated' on his experiments, removing outliers and generally 'tidying' datasets - statistics, and repeating the experiments, shows that his results were just 'too perfect', a point first noted by the Godfather of statistics, RA Fisher, in 1936: http://www.cs.brown.edu/courses/csci1950-l/presentations/REVISED--AFCB%202007%20Course%20Fisher%20and%20Mendel.ppt

Biochemistry of dominance and extensions to expression of traits

The biochemistry of the intermediate proteins determines how they interact in the cell. Therefore, biochemistry predicts how different combinations of alleles will produce varying traits.

Extended expression patterns seen in diploid organisms include facets of incomplete dominance, codominance, and multiple alleles.

See also

Citations

  1. ^ Lawrence, Eleanor (2005) Henderson's Dictionary of Biology. Pearson, Prentice Hall. ISBN 0-13-127384-1
  2. ^ *Campbell, Neil; Reece, Jane (March 2011) [2002], "14", Biology (Sixth ed.), Benjamin Cummings 

References

  • Lawrence>Lawrence, Eleanor (2005) Henderson's Dictionary of Biology. Pearson, Prentice Hall. ISBN 0-13-127384-1
  • Campbell, Neil; Reece, Jane (March 2011) [2002], "14", Biology (Sixth ed.), Benjamin Cummings 

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