Dishevelled

Dishevelled specific domain
Solution structure of the mouse Dvl-1 DEP domain based on the PDB 1fsh coordinates.
Identifiers
Symbol	Dishevelled
Pfam	PF02377
InterPro	IPR003351
PROSITE	PDOC50841
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors.^[1] It takes its name from its initial discovery in flies, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs.^[2]

Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation and cell polarity to social behavior.^[3]

Members

There are three human genes that encode dishevelled proteins:^[4]

• DVL1
• DVL2
• DVL3

Overview of signal transduction pathways involved in apoptosis.

References

1. ^ Penton A, Wodarz A, Nusse R (June 2002). "A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin". Genetics 161 (2): 747–62. PMC 1462152. PMID 12072470. http://www.genetics.org/cgi/pmidlookup?view=long&pmid=12072470. 
2. ^ Wallingford J; Habas R (2005). "The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity". Development 132 (20): 4421–4436. http://dev.biologists.org/content/132/20/4421.full. Retrieved 31 August 2011. 
3. ^ Wallingford JB, Habas R (October 2005). "The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity". Development 132 (20): 4421–36. doi:10.1242/dev.02068. PMID 16192308. 
4. ^ Lee YN, Gao Y, Wang HY (February 2008). "Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3". Cell. Signal. 20 (2): 443–52. doi:10.1016/j.cellsig.2007.11.005. PMC 2233603. PMID 18093802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2233603. 

External links

• MeSH dishevelled proteins

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Protein stubs Protein families Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Synonyms: Disordered (as the hair), untrimmed, hanging loose or negligently, at loose ends R359 road Center Point, Louisiana Look at other dictionaries: dishevelled — (US disheveled) ► ADJECTIVE ▪ (of a person s hair, clothes, or appearance) untidy; disordered. DERIVATIVES dishevelment noun. ORIGIN originally in the sense «having the hair uncovered»: from Old French deschevele, from Latin capillus hair …   English terms dictionary dishevelled — [15] Semantically, dishevelled ‘with untidy hair’ and unkempt ‘with uncombed hair’ are closely parallel formations. Dishevelled originated as an adaptation of deschevele, the past participle of Old French descheveler ‘disarrange the hair’. This… …   The Hutchinson dictionary of word origins dishevelled — [15] Semantically, dishevelled ‘with untidy hair’ and unkempt ‘with uncombed hair’ are closely parallel formations. Dishevelled originated as an adaptation of deschevele, the past participle of Old French descheveler ‘disarrange the hair’. This… …   Word origins dishevelled — di|shev|elled BrE disheveled AmE [dıˈʃevəld] adj [Date: 1300 1400; : Old French; Origin: deschevelé, from chevel hair ] if someone s appearance or their clothes, hair etc is dishevelled, they look very untidy ▪ Pam arrived late, dishevelled and… …   Dictionary of contemporary English dishevelled — [[t]dɪʃe̱v(ə)ld[/t]] ADJ GRADED If you describe someone s hair, clothes, or appearance as dishevelled, you mean that it is very untidy. She arrived flushed and dishevelled. Syn: unkempt (in AM, use disheveled) …   English dictionary dishevelled — BrE, disheveled AmE adjective dishevelled clothes, hair etc are very untidy: Pam arrived late, dishevelled and out of breath …   Longman dictionary of contemporary English dishevelled — /dɪˈʃɛvəld / (say di shevuhld) adjective 1. hanging loosely or in disorder; unkempt: dishevelled hair. 2. untidy; disarranged: dishevelled appearance. Also, US, disheveled …   dishevelled — disheveled di*shev eled, dishevelled di*shev elled, a. 1. Hanging in loose disorder; disarranged; in disarray; not made neat; used especially of hair or clothing; as, disheveled hair. [1913 Webster] 2. Having the hair in loose disorder. [1913… …   The Collaborative International Dictionary of English Dishevelled — Dishevel Di*shev el (d[i^]*sh[e^]v l or [e^]l), v. t. [imp. & p. p. {Disheveled}or {Dishevelled}; p. pr. & vb. n. {Disheveling} or {Dishevelling}.] [OF. descheveler, F. d[ e]cheveler, LL. discapillare; dis + L. capillus the hair of the head. See… …   The Collaborative International Dictionary of English dishevelled — adj. Dishevelled/disheveled is used with these nouns: ↑appearance, ↑clothes, ↑hair …   Collocations dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”