DVL2

Dishevelled, dsh homolog 2 (Drosophila)
PDB rendering based on 1l6o.
Available structures PDB 2REY, 3CBX, 3CBY, 3CBZ, 3CC0
Identifiers
Symbols	DVL2;
External IDs	OMIM: 602151 MGI: 106613 HomoloGene: 20927 GeneCards: DVL2 Gene
Gene Ontology Molecular function • signal transducer activity • frizzled binding • protein binding • protein domain specific binding • identical protein binding Cellular component • nucleus • cytoplasm • cytosol • plasma membrane • cytoplasmic membrane-bounded vesicle • clathrin-coated vesicle • apical part of cell Biological process • neural tube closure • positive regulation of protein phosphorylation • heart morphogenesis • transcription from RNA polymerase II promoter • multicellular organismal development • segment specification • heart development • convergent extension involved in neural plate elongation • cellular protein localization • intracellular signal transduction • non-canonical Wnt receptor signaling pathway • positive regulation of JUN kinase activity • positive regulation of JUN kinase activity • canonical Wnt receptor signaling pathway involved in regulation of cell proliferation • positive regulation of transcription, DNA-dependent • positive regulation of sequence-specific DNA binding transcription factor activity • canonical Wnt receptor signaling pathway • Wnt receptor signaling pathway, planar cell polarity pathway • positive regulation of protein tyrosine kinase activity • cochlea morphogenesis • planar cell polarity pathway involved in neural tube closure Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1856	13543
Ensembl	ENSG00000004975	ENSMUSG00000020888
UniProt	O14641	Q3V330
RefSeq (mRNA)	NM_004422	NM_007888.3
RefSeq (protein)	NP_004413	NP_031914.3
Location (UCSC)	Chr 17: 7.13 – 7.14 Mb	Chr 11: 69.81 – 69.83 Mb
PubMed search	[1]	[2]

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.^[1][2]

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.^[2]

Interactions

DVL2 has been shown to interact with Zinc finger protein 165,^[3] DAB2^[4] and Arrestin beta 1.^[5]

See also

• Dishevelled

References

1. ^ Greco TL, Sussman DJ, Camper SA (January1997). "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11". Mamm Genome 7 (6): 475–6. doi:10.1007/s003359900144. PMID 8662242. 
2. ^ ^{a b} "Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1856. 
3. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
4. ^ Hocevar, B A; Mou F, Rennolds J L, Morris S M, Cooper J A, Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. (England) 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=162138. 
5. ^ Chen, W; Hu L A, Semenov M V, Yanagawa S, Kikuchi A, Lefkowitz R J, Miller W E (December 2001). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (26): 14889–94. doi:10.1073/pnas.211572798. ISSN 0027-8424. PMC 64954. PMID 11742073. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=64954. 

Further reading

• Pizzuti A, Amati F, Calabrese G, et al. (1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum. Mol. Genet. 5 (7): 953–8. doi:10.1093/hmg/5.7.953. PMID 8817329. 
• Klingensmith J, Yang Y, Axelrod JD, et al. (1997). "Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2". Mech. Dev. 58 (1–2): 15–26. doi:10.1016/S0925-4773(96)00549-7. PMID 8887313. 
• Semënov MV, Snyder M (1997). "Human dishevelled genes constitute a DHR-containing multigene family". Genomics 42 (2): 302–10. doi:10.1006/geno.1997.4713. PMID 9192851. 
• Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription". J. Biol. Chem. 275 (4): 2399–403. doi:10.1074/jbc.275.4.2399. PMID 10644691. 
• Song DH, Sussman DJ, Seldin DC (2000). "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells". J. Biol. Chem. 275 (31): 23790–7. doi:10.1074/jbc.M909107199. PMID 10806215. 
• Zhang Y, Neo SY, Han J, Lin SC (2000). "Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase". J. Biol. Chem. 275 (32): 25008–14. doi:10.1074/jbc.M002491200. PMID 10829020. 
• Chen W, Hu LA, Semenov MV, et al. (2002). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14889–94. doi:10.1073/pnas.211572798. PMC 64954. PMID 11742073. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=64954. 
• Habas R, Kato Y, He X (2002). "Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1". Cell 107 (7): 843–54. doi:10.1016/S0092-8674(01)00614-6. PMID 11779461. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Habas R, Dawid IB, He X (2003). "Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation". Genes Dev. 17 (2): 295–309. doi:10.1101/gad.1022203. PMC 195976. PMID 12533515. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=195976. 
• Chen W, ten Berge D, Brown J, et al. (2003). "Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4". Science 301 (5638): 1391–4. doi:10.1126/science.1082808. PMID 12958364. 
• Wong CK, Luo W, Deng Y, et al. (2004). "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms". J. Biol. Chem. 279 (38): 39366–73. doi:10.1074/jbc.M404598200. PMID 15262978. 
• Torban E, Wang HJ, Groulx N, Gros P (2005). "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family". J. Biol. Chem. 279 (50): 52703–13. doi:10.1074/jbc.M408675200. PMID 15456783. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Zhang L, Gao X, Wen J, et al. (2006). "Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation". J. Biol. Chem. 281 (13): 8607–12. doi:10.1074/jbc.M600274200. PMID 16446366. 
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.