Naked cuticle 2

Naked cuticle 2

Naked cuticle 2 (NKD2) is a human gene that encodes the protein Nkd2, one of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway[1][2]. Both Nkd1 and Nkd2 proteins can bind to Dishevelled proteins (DVL1, DVL2, DVL3), but only Nkd2 can bind to the EGF-ligand family member TGF alpha and regulate its polarized secretion in cultured epithelial cells [3].

Sources

  1. ^ Wharton KA Jr, Zimmermann G, Rousset R, Scott MP. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol. 2001 Jun 1;234(1):93-106. PMID: 11356022
  2. ^ Katoh M. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. Int J Oncol. 2001 Nov;19(5):963-9. PMID: 11604995
  3. ^ Li C, Franklin JL, Graves-Deal R, Jerome WG, Cao Z, Coffey RJ. Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5571-6. Epub 2004 Apr 2.PMID: 15064403

Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Naked cuticle — (Nkd) is a conserved family of intracellular proteins encoded in the genomes of diverse animals, including nearly all insects and vertebrates studied to date. The original mutants were discovered by 1995 Nobel laureates Christiane Nüsslein… …   Wikipedia

  • Naked cuticle 1 — (NKD1) is a human gene that encodes the protein Nkd1, a member of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway[1][2][3]. Genome sequence analyses thus far indicate that insects typically have a single Nkd… …   Wikipedia

  • Naked (disambiguation) — Naked most commonly refers to the state of nudity. Naked may also refer to: Contents 1 Albums 2 Songs 3 Other uses …   Wikipedia

  • Drosophila embryogenesis — Drosophila embryogenesis, the process by which Drosophila (fruit fly) embryos form, is a favorite model system for geneticists and developmental biologists studying embryogenesis. The small size, short generation time, and large brood size make… …   Wikipedia

  • integument — /in teg yeuh meuhnt/, n. 1. a natural covering, as a skin, shell, or rind. 2. any covering, coating, enclosure, etc. [1605 15; < L integumentum a covering. See IN 2, TEGUMENT] Syn. 1. cortex, involucre, involucrum. * * * Covering of the body,… …   Universalium

  • Hair — For other uses, see Hair (disambiguation). Hairy redirects here. For individuals nicknamed the Hairy , see List of people known as the Hairy. Hair Cross section of a hair Latin unguis …   Wikipedia

  • tree — treelike, adj. /tree/, n., v., treed, treeing. n. 1. a plant having a permanently woody main stem or trunk, ordinarily growing to a considerable height, and usually developing branches at some distance from the ground. 2. any of various shrubs,… …   Universalium

  • Tree — /tree/, n. Sir Herbert Beerbohm /bear bohm/, (Herbert Beerbohm), 1853 1917, English actor and theater manager; brother of Max Beerbohm. * * * I Woody perennial plant. Most trees have a single self supporting trunk containing woody tissues, and in …   Universalium

  • animal development — Introduction  the processes that lead eventually to the formation of a new animal starting from cells derived from one or more parent individuals. Development thus occurs following the process by which a new generation of organisms is produced by …   Universalium

  • skeleton — skeletonless, adj. skeletonlike, adj. /skel i tn/, n. 1. Anat., Zool. the bones of a human or an animal considered as a whole, together forming the framework of the body. 2. any of various structures forming a rigid framework in an invertebrate.… …   Universalium

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”