DVL1

Dishevelled, dsh homolog 1 (Drosophila)
PDB rendering based on 1fsh.
Available structures PDB 1fsh, 1mc7
Identifiers
Symbols	DVL1; DVL; DVL1L1; MGC54245
External IDs	OMIM: 601365 MGI: 94941 HomoloGene: 20926 GeneCards: DVL1 Gene
Gene Ontology Molecular function • molecular_function • signal transducer activity • frizzled binding • protein binding • enzyme binding • protein kinase binding • protein kinase binding • identical protein binding • Rac GTPase binding Cellular component • cytoplasm • cytoplasm • cytosol • microtubule • plasma membrane • cytoplasmic membrane-bounded vesicle • cytoplasmic membrane-bounded vesicle • synaptosome • synaptosome • clathrin-coated vesicle • axon • dendrite • growth cone • cytoplasmic vesicle • neuronal cell body • synapse • synapse Biological process • regulation of neurotransmitter levels • negative regulation of protein phosphorylation • transcription from RNA polymerase II promoter • negative regulation of protein kinase activity • signal transduction • neurotransmitter secretion • neurotransmitter secretion • multicellular organismal development • axon guidance • heart development • neuromuscular junction development • positive regulation of neuron projection development • neural tube development • convergent extension involved in neural plate elongation • positive regulation of Wnt receptor signaling pathway • cytoplasmic microtubule organization • negative regulation of protein binding • protein localization to nucleus • social behavior • protein localization to microtubule • intracellular signal transduction • receptor clustering • positive regulation of transcription, DNA-dependent • collateral sprouting • axon extension • dendrite morphogenesis • dendrite morphogenesis • synapse organization • canonical Wnt receptor signaling pathway • Wnt receptor signaling pathway, planar cell polarity pathway • prepulse inhibition • skeletal muscle nicotinic acetylcholine receptor clustering • cochlea morphogenesis • planar cell polarity pathway involved in neural tube closure • positive regulation of canonical Wnt receptor signaling pathway
Orthologs
Species	Human	Mouse
Entrez	1855	13542
Ensembl	ENSG00000107404	ENSMUSG00000029071
UniProt	n/a	Q3TRW4
RefSeq (mRNA)	NM_004421	NM_010091.3
RefSeq (protein)	NP_004412	NP_034221.3
Location (UCSC)	Chr 1: 1.27 – 1.28 Mb	Chr 4: 155.22 – 155.23 Mb
PubMed search	[1]	[2]

Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene.^[1][2]

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.^[2]

Interactions

DVL1 has been shown to interact with DVL3,^[3] EPS8,^[4] AXIN1^[5][6] and Mothers against decapentaplegic homolog 3.^[7]

See also

• Dishevelled

References

1. ^ Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B (Jan 1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum Mol Genet 5 (7): 953–8. doi:10.1093/hmg/5.7.953. PMID 8817329. 
2. ^ ^{a b} "Entrez Gene: DVL1 dishevelled, dsh homolog 1 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1855. 
3. ^ Kishida, S; Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A (Jun. 1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. (UNITED STATES) 19 (6): 4414–22. ISSN 0270-7306. PMC 104400. PMID 10330181. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=104400. 
4. ^ Inobe, M; Katsube K i, Miyagoe Y, Nabeshima Y i, Takeda S (Dec. 1999). "Identification of EPS8 as a Dvl1-associated molecule". Biochem. Biophys. Res. Commun. (UNITED STATES) 266 (1): 216–21. doi:10.1006/bbrc.1999.1782. ISSN 0006-291X. PMID 10581192. 
5. ^ Li, L; Yuan H, Weaver C D, Mao J, Farr G H, Sussman D J, Jonkers J, Kimelman D, Wu D (Aug. 1999). "Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1". EMBO J. (ENGLAND) 18 (15): 4233–40. doi:10.1093/emboj/18.15.4233. ISSN 0261-4189. PMC 1171499. PMID 10428961. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171499. 
6. ^ Kim, Min Jung; Chia Ian V, Costantini Frank (Nov. 2008). "SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability". FASEB J. (United States) 22 (11): 3785–94. doi:10.1096/fj.08-113910. PMC 2574027. PMID 18632848. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2574027. 
7. ^ Warner, Dennis R; Pisano M Michele, Roberts Emily A, Greene Robert M (Mar. 2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. (Netherlands) 539 (1-3): 167–73. doi:10.1016/S0014-5793(03)00155-8. ISSN 0014-5793. PMID 12650946. 

Further reading

• Wharton KA (2003). "Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction.". Dev. Biol. 253 (1): 1–17. doi:10.1006/dbio.2002.0869. PMID 12490194. 
• Klingensmith J, Nusse R, Perrimon N (1994). "The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.". Genes Dev. 8 (1): 118–30. doi:10.1101/gad.8.1.118. PMID 8288125. 
• Pizzuti A, Novelli G, Mari A, et al. (1996). "Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.". Am. J. Hum. Genet. 58 (4): 722–9. PMC 1914677. PMID 8644734. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1914677. 
• Steitz SA, Tsang M, Sussman DJ (1997). "Wnt-mediated relocalization of dishevelled proteins.". In Vitro Cell. Dev. Biol. Anim. 32 (7): 441–5. doi:10.1007/BF02723007. PMID 8856345. 
• Semënov MV, Snyder M (1997). "Human dishevelled genes constitute a DHR-containing multigene family.". Genomics 42 (2): 302–10. doi:10.1006/geno.1997.4713. PMID 9192851. 
• Bui TD, Beier DR, Jonssen M, et al. (1997). "cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.". Biochem. Biophys. Res. Commun. 239 (2): 510–6. doi:10.1006/bbrc.1997.7500. PMID 9344861. 
• Ikeda S, Kishida S, Yamamoto H, et al. (1998). "Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.". EMBO J. 17 (5): 1371–84. doi:10.1093/emboj/17.5.1371. PMC 1170485. PMID 9482734. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170485. 
• Kishida S, Yamamoto H, Hino S, et al. (1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.". Mol. Cell. Biol. 19 (6): 4414–22. PMC 104400. PMID 10330181. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=104400. 
• Fagotto F, Jho E, Zeng L, et al. (1999). "Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.". J. Cell Biol. 145 (4): 741–56. doi:10.1083/jcb.145.4.741. PMC 2133179. PMID 10330403. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2133179. 
• Li L, Yuan H, Weaver CD, et al. (1999). "Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.". EMBO J. 18 (15): 4233–40. doi:10.1093/emboj/18.15.4233. PMC 1171499. PMID 10428961. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171499. 
• Inobe M, Katsube K, Miyagoe Y, et al. (2000). "Identification of EPS8 as a Dvl1-associated molecule.". Biochem. Biophys. Res. Commun. 266 (1): 216–21. doi:10.1006/bbrc.1999.1782. PMID 10581192. 
• Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.". J. Biol. Chem. 275 (4): 2399–403. doi:10.1074/jbc.275.4.2399. PMID 10644691. 
• Song DH, Sussman DJ, Seldin DC (2000). "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells.". J. Biol. Chem. 275 (31): 23790–7. doi:10.1074/jbc.M909107199. PMID 10806215. 
• Hino S, Kishida S, Michiue T, et al. (2001). "Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.". Mol. Cell. Biol. 21 (1): 330–42. doi:10.1128/MCB.21.1.330-342.2001. PMC 88806. PMID 11113207. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=88806. 
• Rubinfeld B, Tice DA, Polakis P (2001). "Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon.". J. Biol. Chem. 276 (42): 39037–45. doi:10.1074/jbc.M105148200. PMID 11487578. 
• Chen W, Hu LA, Semenov MV, et al. (2002). "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14889–94. doi:10.1073/pnas.211572798. PMC 64954. PMID 11742073. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=64954. 
• Habas R, Kato Y, He X (2002). "Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.". Cell 107 (7): 843–54. doi:10.1016/S0092-8674(01)00614-6. PMID 11779461. 
• Russ C, Lovestone S, Powell JF (2002). "Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease.". Mol. Psychiatry 7 (1): 104–9. doi:10.1038/sj/mp/4000941. PMID 11803455. 
• Gao ZH, Seeling JM, Hill V, et al. (2002). "Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1182–7. doi:10.1073/pnas.032468199. PMC 122164. PMID 11818547. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122164. 

External links

• DVL1 on the Atlas of Genetics and Oncology

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат DDX5 Jijia River (Suceava) Look at other dictionaries: 22q13 deletion syndrome — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD9 = ICDO = OMIM = 606232 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = 22q13 Deletion Syndrome (spoken as twenty two q one three ), also known as Phelan McDermid Syndrome …   Wikipedia Dishevelled — specific domain Solution structure of the mouse Dvl 1 DEP domain based on the PDB 1fsh coordinates. Identifiers …   Wikipedia Síndrome deleción 22q13 — Clasificación y recursos externos OMIM 606232 …   Wikipedia Español PDZ domain — Molecular structure of the PDZ domain included in the human GOPC (Golgi associated PDZ and coiled coil motif containing protein) protein Identifiers Symbol PDZ …   Wikipedia DVL — could refer to: Damn Vulnerable Linux, a Linux distribution designed for IT Security training. Davitamon Lotto, former name of the Belgian cycling team Omega Pharma Lotto Dearne Valley Line, a railway line in England Desert Valley League, a high… …   Wikipedia EPS8 — Epidermal growth factor receptor pathway substrate 8, also known as EPS8, is a human gene.cite web | title = Entrez Gene: EPS8 epidermal growth factor receptor pathway substrate 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia DVL3 — Dishevelled, dsh homolog 3 (Drosophila) PDB rendering based on 1l6o …   Wikipedia Naked cuticle 1 — (NKD1) is a human gene that encodes the protein Nkd1, a member of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway[1][2][3]. Genome sequence analyses thus far indicate that insects typically have a single Nkd… …   Wikipedia Naked cuticle 2 — (NKD2) is a human gene that encodes the protein Nkd2, one of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway[1][2]. Both Nkd1 and Nkd2 proteins can bind to Dishevelled proteins (DVL1, DVL2, DVL3), but only Nkd2… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”