EPS8

Epidermal growth factor receptor pathway substrate 8, also known as EPS8, is a human gene.cite web | title = Entrez Gene: EPS8 epidermal growth factor receptor pathway substrate 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2059| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.cite web | title = Entrez Gene: EPS8 epidermal growth factor receptor pathway substrate 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2059| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Di Fiore PP, Scita G |title=Eps8 in the midst of GTPases. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 10 |pages= 1178–83 |year= 2002 |pmid= 12127568 |doi=
*cite journal | author=Cardwell C |title=Student or worker? International Meeting of Student Nurses (European Group). |journal=Nursing mirror and midwives journal |volume=143 |issue= 19 |pages= 38 |year= 1977 |pmid= 1049958 |doi=
*cite journal | author=Castagnino P, Biesova Z, Wong WT, "et al." |title=Direct binding of eps8 to the juxtamembrane domain of EGFR is phosphotyrosine- and SH2-independent. |journal=Oncogene |volume=10 |issue= 4 |pages= 723–9 |year= 1995 |pmid= 7532293 |doi=
*cite journal | author=Karlsson T, Songyang Z, Landgren E, "et al." |title=Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins. |journal=Oncogene |volume=10 |issue= 8 |pages= 1475–83 |year= 1995 |pmid= 7537362 |doi=
*cite journal | author=Avantaggiato V, Torino A, Wong WT, "et al." |title=Expression of the receptor tyrosine kinase substrate genes eps8 and eps15 during mouse development. |journal=Oncogene |volume=11 |issue= 6 |pages= 1191–8 |year= 1995 |pmid= 7566980 |doi=
*cite journal | author=Matoskova B, Wong WT, Salcini AE, "et al." |title=Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation. |journal=Mol. Cell. Biol. |volume=15 |issue= 7 |pages= 3805–12 |year= 1995 |pmid= 7791787 |doi=
*cite journal | author=Wong WT, Carlomagno F, Druck T, "et al." |title=Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24. |journal=Oncogene |volume=9 |issue= 10 |pages= 3057–61 |year= 1994 |pmid= 8084614 |doi=
*cite journal | author=Fazioli F, Minichiello L, Matoska V, "et al." |title=Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals. |journal=EMBO J. |volume=12 |issue= 10 |pages= 3799–808 |year= 1993 |pmid= 8404850 |doi=
*cite journal | author=Matòsková B, Wong WT, Seki N, "et al." |title=RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain. |journal=Oncogene |volume=12 |issue= 12 |pages= 2563–71 |year= 1996 |pmid= 8700515 |doi=
*cite journal | author=Matòsková B, Wong WT, Nomura N, "et al." |title=RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 upon carboxy-terminal truncation. |journal=Oncogene |volume=12 |issue= 12 |pages= 2679–88 |year= 1996 |pmid= 8700527 |doi=
*cite journal | author=Biesova Z, Piccoli C, Wong WT |title=Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth. |journal=Oncogene |volume=14 |issue= 2 |pages= 233–41 |year= 1997 |pmid= 9010225 |doi= 10.1038/sj.onc.1200822
*cite journal | author=Kishan KV, Scita G, Wong WT, "et al." |title=The SH3 domain of Eps8 exists as a novel intertwined dimer. |journal=Nat. Struct. Biol. |volume=4 |issue= 9 |pages= 739–43 |year= 1997 |pmid= 9303002 |doi=
*cite journal | author=Maa MC, Lai JR, Lin RW, Leu TH |title=Enhancement of tyrosyl phosphorylation and protein expression of eps8 by v-Src. |journal=Biochim. Biophys. Acta |volume=1450 |issue= 3 |pages= 341–51 |year= 1999 |pmid= 10395945 |doi=
*cite journal | author=Scita G, Nordstrom J, Carbone R, "et al." |title=EPS8 and E3B1 transduce signals from Ras to Rac. |journal=Nature |volume=401 |issue= 6750 |pages= 290–3 |year= 1999 |pmid= 10499589 |doi= 10.1038/45822
*cite journal | author=Inobe M, Katsube K, Miyagoe Y, "et al." |title=Identification of EPS8 as a Dvl1-associated molecule. |journal=Biochem. Biophys. Res. Commun. |volume=266 |issue= 1 |pages= 216–21 |year= 2000 |pmid= 10581192 |doi= 10.1006/bbrc.1999.1782
*cite journal | author=Lanzetti L, Rybin V, Malabarba MG, "et al." |title=The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. |journal=Nature |volume=408 |issue= 6810 |pages= 374–7 |year= 2000 |pmid= 11099046 |doi= 10.1038/35042605
*cite journal | author=Ion A, Crosby AH, Kremer H, "et al." |title=Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6. |journal=J. Med. Genet. |volume=37 |issue= 11 |pages= 884–6 |year= 2000 |pmid= 11185075 |doi=
*cite journal | author=Scita G, Tenca P, Areces LB, "et al." |title=An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine. |journal=J. Cell Biol. |volume=154 |issue= 5 |pages= 1031–44 |year= 2001 |pmid= 11524436 |doi= 10.1083/jcb.200103146
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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