AXIN1

Axin 1, also known as AXIN1, is a human gene.

PBB_Summary
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summary_text = This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [cite web | title = Entrez Gene: AXIN1 axin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8312| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Segditsas S, Tomlinson I |title=Colorectal cancer and genetic alterations in the Wnt pathway. |journal=Oncogene |volume=25 |issue= 57 |pages= 7531–7 |year= 2007 |pmid= 17143297 |doi= 10.1038/sj.onc.1210059
*cite journal | author=Flint J, Thomas K, Micklem G, "et al." |title=The relationship between chromosome structure and function at a human telomeric region. |journal=Nat. Genet. |volume=15 |issue= 3 |pages= 252–7 |year= 1997 |pmid= 9054936 |doi= 10.1038/ng0397-252
*cite journal | author=Zeng L, Fagotto F, Zhang T, "et al." |title=The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. |journal=Cell |volume=90 |issue= 1 |pages= 181–92 |year= 1997 |pmid= 9230313 |doi=
*cite journal | author=Ikeda S, Kishida S, Yamamoto H, "et al." |title=Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. |journal=EMBO J. |volume=17 |issue= 5 |pages= 1371–84 |year= 1998 |pmid= 9482734 |doi= 10.1093/emboj/17.5.1371
*cite journal | author=Hart MJ, de los Santos R, Albert IN, "et al." |title=Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. |journal=Curr. Biol. |volume=8 |issue= 10 |pages= 573–81 |year= 1998 |pmid= 9601641 |doi=
*cite journal | author=Nakamura T, Hamada F, Ishidate T, "et al." |title=Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. |journal=Genes Cells |volume=3 |issue= 6 |pages= 395–403 |year= 1998 |pmid= 9734785 |doi=
*cite journal | author=Hsu W, Zeng L, Costantini F |title=Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3439–45 |year= 1999 |pmid= 9920888 |doi=
*cite journal | author=Kitagawa M, Hatakeyama S, Shirane M, "et al." |title=An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. |journal=EMBO J. |volume=18 |issue= 9 |pages= 2401–10 |year= 1999 |pmid= 10228155 |doi= 10.1093/emboj/18.9.2401
*cite journal | author=Fagotto F, Jho E, Zeng L, "et al." |title=Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. |journal=J. Cell Biol. |volume=145 |issue= 4 |pages= 741–56 |year= 1999 |pmid= 10330403 |doi=
*cite journal | author=Kodama S, Ikeda S, Asahara T, "et al." |title=Axin directly interacts with plakoglobin and regulates its stability. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27682–8 |year= 1999 |pmid= 10488109 |doi=
*cite journal | author=Jho E, Lomvardas S, Costantini F |title=A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. |journal=Biochem. Biophys. Res. Commun. |volume=266 |issue= 1 |pages= 28–35 |year= 2000 |pmid= 10581160 |doi= 10.1006/bbrc.1999.1760
*cite journal | author=Ikeda S, Kishida M, Matsuura Y, "et al." |title=GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. |journal=Oncogene |volume=19 |issue= 4 |pages= 537–45 |year= 2000 |pmid= 10698523 |doi= 10.1038/sj.onc.1203359
*cite journal | author=Satoh S, Daigo Y, Furukawa Y, "et al." |title=AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. |journal=Nat. Genet. |volume=24 |issue= 3 |pages= 245–50 |year= 2000 |pmid= 10700176 |doi= 10.1038/73448
*cite journal | author=Spink KE, Polakis P, Weis WI |title=Structural basis of the Axin-adenomatous polyposis coli interaction. |journal=EMBO J. |volume=19 |issue= 10 |pages= 2270–9 |year= 2000 |pmid= 10811618 |doi= 10.1093/emboj/19.10.2270
*cite journal | author=Zhang Y, Neo SY, Han J, Lin SC |title=Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 25008–14 |year= 2000 |pmid= 10829020 |doi= 10.1074/jbc.M002491200
*cite journal | author=Daniels RJ, Peden JF, Lloyd C, "et al." |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=
*cite journal | author=Yamamoto H, Hinoi T, Michiue T, "et al." |title=Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A. |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 26875–82 |year= 2001 |pmid= 11297546 |doi= 10.1074/jbc.M100443200
*cite journal | author=Mao J, Wang J, Liu B, "et al." |title=Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. |journal=Mol. Cell |volume=7 |issue= 4 |pages= 801–9 |year= 2001 |pmid= 11336703 |doi=
*cite journal | author=Furuhashi M, Yagi K, Yamamoto H, "et al." |title=Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway. |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5132–41 |year= 2001 |pmid= 11438668 |doi= 10.1128/MCB.21.15.5132-5141.2001
*cite journal | author=Rubinfeld B, Tice DA, Polakis P |title=Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39037–45 |year= 2001 |pmid= 11487578 |doi= 10.1074/jbc.M105148200

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