WNT5A

Wingless-type MMTV integration site family, member 5A, also known as WNT5A, is a human gene.cite web | title = Entrez Gene: WNT5A wingless-type MMTV integration site family, member 5A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7474| accessdate = ]

PBB_Summary
section_title =
summary_text = The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98%, 98% and 87% amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction.cite web | title = Entrez Gene: WNT5A wingless-type MMTV integration site family, member 5A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7474| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Smolich BD, McMahon JA, McMahon AP, Papkoff J |title=Wnt family proteins are secreted and associated with the cell surface. |journal=Mol. Biol. Cell |volume=4 |issue= 12 |pages= 1267–75 |year= 1994 |pmid= 8167409 |doi=
*cite journal | author=Clark CC, Cohen I, Eichstetter I, "et al." |title=Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. |journal=Genomics |volume=18 |issue= 2 |pages= 249–60 |year= 1994 |pmid= 8288227 |doi= 10.1006/geno.1993.1463
*cite journal | author=Danielson KG, Pillarisetti J, Cohen IR, "et al." |title=Characterization of the complete genomic structure of the human WNT-5A gene, functional analysis of its promoter, chromosomal mapping, and expression in early human embryogenesis. |journal=J. Biol. Chem. |volume=270 |issue= 52 |pages= 31225–34 |year= 1996 |pmid= 8537388 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=He X, Saint-Jeannet JP, Wang Y, "et al." |title=A member of the Frizzled protein family mediating axis induction by Wnt-5A. |journal=Science |volume=275 |issue= 5306 |pages= 1652–4 |year= 1997 |pmid= 9054360 |doi=
*cite journal | author=Wright M, Aikawa M, Szeto W, Papkoff J |title=Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 2 |pages= 384–8 |year= 1999 |pmid= 10491302 |doi= 10.1006/bbrc.1999.1344
*cite journal | author=Gazit A, Yaniv A, Bafico A, "et al." |title=Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. |journal=Oncogene |volume=18 |issue= 44 |pages= 5959–66 |year= 1999 |pmid= 10557084 |doi= 10.1038/sj.onc.1202985
*cite journal | author=Saitoh T, Mine T, Katoh M |title=Frequent up-regulation of WNT5A mRNA in primary gastric cancer. |journal=Int. J. Mol. Med. |volume=9 |issue= 5 |pages= 515–9 |year= 2002 |pmid= 11956659 |doi=
*cite journal | author=Weeraratna AT, Jiang Y, Hostetter G, "et al." |title=Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. |journal=Cancer Cell |volume=1 |issue= 3 |pages= 279–88 |year= 2002 |pmid= 12086864 |doi=
*cite journal | author=Saitoh T, Katoh M |title=Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells. |journal=Int. J. Mol. Med. |volume=10 |issue= 3 |pages= 345–9 |year= 2003 |pmid= 12165812 |doi=
*cite journal | author=Murphy LL, Hughes CC |title=Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway. |journal=J. Immunol. |volume=169 |issue= 7 |pages= 3717–25 |year= 2002 |pmid= 12244165 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ishitani T, Kishida S, Hyodo-Miura J, "et al." |title=The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 131–9 |year= 2003 |pmid= 12482967 |doi=
*cite journal | author=Hocevar BA, Mou F, Rennolds JL, "et al." |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2). |journal=EMBO J. |volume=22 |issue= 12 |pages= 3084–94 |year= 2003 |pmid= 12805222 |doi= 10.1093/emboj/cdg286
*cite journal | author=Taki M, Kamata N, Yokoyama K, "et al." |title=Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. |journal=Cancer Sci. |volume=94 |issue= 7 |pages= 593–7 |year= 2004 |pmid= 12841867 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Glinsky GV, Glinskii AB, Stephenson AJ, "et al." |title=Gene expression profiling predicts clinical outcome of prostate cancer. |journal=J. Clin. Invest. |volume=113 |issue= 6 |pages= 913–23 |year= 2004 |pmid= 15067324 |doi= 10.1172/JCI200420032
*cite journal | author=Nishioka K, Dennis JE, Gao J, "et al." |title=Sustained Wnt protein expression in chondral constructs from mesenchymal stem cells. |journal=J. Cell. Physiol. |volume=203 |issue= 1 |pages= 6–14 |year= 2005 |pmid= 15389636 |doi= 10.1002/jcp.20196
*cite journal | author=Blanc E, Roux GL, Bénard J, Raguénez G |title=Low expression of Wnt-5a gene is associated with high-risk neuroblastoma. |journal=Oncogene |volume=24 |issue= 7 |pages= 1277–83 |year= 2005 |pmid= 15592517 |doi= 10.1038/sj.onc.1208255
*cite journal | author=Kremenevskaja N, von Wasielewski R, Rao AS, "et al." |title=Wnt-5a has tumor suppressor activity in thyroid carcinoma. |journal=Oncogene |volume=24 |issue= 13 |pages= 2144–54 |year= 2005 |pmid= 15735754 |doi= 10.1038/sj.onc.1208370

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