Neurophysin II

arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)
Identifiers
Symbol	AVP
Alt. symbols	ARVP
Entrez	551
HUGO	894
OMIM	192340
RefSeq	NM_000490
UniProt	P01185
Other data
Locus	Chr. 20 p13

Neurophysin II is a carrier protein which binds vasopressin. It is generated from the same precursor as vasopressin.

It can be associated with neurohypophyseal diabetes insipidus.^[1]

Neurophysin II is also known as a stimulator of Prolactin secretion.

Structure

The amino acid sequence of Neurophysin II is:

NH₂ - Ala - Met - Ser - Asp - Leu - Glu - Leu - Arg - Gln - Cys - Leu - Pro - Cys - Gly - Pro - Gly - Gly - Lys - Gly - Arg - Cys - Phe - Gly - Pro - Ser - Ile - Cys - Cys - Ala - Asp - Glu - Leu - Gly - Cys - Phe - Val - Gly - Thr - Ala - Glu - Ala - Leu - Arg - Cys - Gln - Glu - Glu - Asn - Tyr - Leu - Pro - Ser - Pro - Cys - Gln - Ser - Gly - Gln - Lys - Ala - Cys - Gly - Ser - Gly - Gly - Arg - Cys - Ala - Ala - Phe - Gly - Val - Cys - Cys - Asn - Asp - Glu - Ser - Cys - Val - Thr - Glu - Pro - Glu - Cys - Arg - Glu - Gly - Phe - His - Arg - Arg - Ala - OH

(Disulfide - bridge: - 10-54; - 13-27; - 21-44; - 28-34; - 61-73; - 67-85; - 74-79)

Clinical significance

Point mutations in neurophysin II underline most cases of hereditary hypothalamic diabetes insipidus, a disorder resulting from insufficient ADH release into systemic circulation.

References

1. ^ Christensen JH, Siggaard C, Corydon TJ, et al (January 2004). "Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis". Eur. J. Hum. Genet. 12 (1): 44–51. doi:10.1038/sj.ejhg.5201086. PMID 14673472. 

External links

• MeSH Neurophysin+II