- Odorant binding protein
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Pheromone/general odorant binding protein Identifiers Symbol PBP_GOBP Pfam PF01395 InterPro IPR006170 SCOP 1c3z Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary odorant binding protein 2A 
Identifiers Symbol OBP2A Alt. symbols hOBPIIa, OBP Entrez 29991 HUGO 23380 OMIM 164320 RefSeq NM_014582 UniProt Q9NY56 Other data Locus Chr. 9 q34 odorant binding protein 2B Crystal Structure of an Anopheles gambiae Odorant-binding Protein AgamOBP22a with Bound Odorant Cyclohexanone [1] Identifiers Symbol OBP2B Alt. symbols hOBPIIb Entrez 29989 HUGO 23381 OMIM 604606 RefSeq NM_014581 UniProt Q9NPH6 Other data Locus Chr. 9 q34 Odorant binding proteins are abundant small soluble proteins secreted in the nasal mucus of many animal species and in the sensillar lymph of chemosensory sensilla of insects.
The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is greatly enhanced via odorant binding proteins which exist in the extracellular fluid surrounding the odorant receptors[2]. This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant binding proteins (GOBP).
These proteins were initially identified on the basis of their ability to bind with moderate affinity radioactively labeled odorants.[3][4]
References
- ^ Yang G, Winberg G, Ren H, Zhang S (February 2011). "Expression, purification and functional analysis of an odorant binding protein AaegOBP22 from Aedes aegypti". Protein Expr. Purif. 75 (2): 165–71. doi:10.1016/j.pep.2010.09.004. PMID 20828619.
- ^ Prestwich GD, Vogt RG, Lerner MR (1991). "Odorant-binding-protein subfamilies associate with distinct classes of olfactory receptor neurons in insects". J. Neurobiol. 22 (1): 74–84. PMID 2010751.
- ^ Pelosi P, Baldaccini NE, Pisanelli AM (January 1982). "Identification of a specific olfactory receptor for 2-isobutyl-3-methoxypyrazine". Biochem. J. 201 (1): 245–8. PMC 1163633. PMID 7082286. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1163633.
- ^ PDB ID: 1CI0 W. Shi, D.A. Ostrov, S.E. Gerchman, V. Graziano, H. Kycia, B. Studier, S.C. Almo, S.K. Burley, New York Structural GenomiX Research Consortium (NYSGXRC). The Structure of PNP Oxidase from S. cerevisiae
Fatty acid Hormone peptide hormone: Follistatin · Growth hormone binding protein · Insulin-like growth factor binding protein (IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6, IGFBP7) · Neurophysins (Neurophysin I, II)
steroid hormone: Sex hormone binding globulin/Androgen binding protein · Transcortin · Thyroxine-binding globulin · TransthyretinMetal/element calcium (Calcium-binding protein, Calmodulin-binding proteins) · copper (Ceruloplasmin) · iron (Iron-binding proteins, Transferrin receptor)Vitamin Other Acyl carrier protein · Adaptor protein · Cholesterylester transfer protein · F-box protein · GTP-binding protein · Latent TGF-beta binding protein · Light-harvesting complex · Major urinary proteins · Membrane transport protein · Odorant binding proteinB proteins: BY STRUCTURE: membrane, globular (en, ca, an), fibrous Categories:- Genes on chromosome 9
- Olfaction
- Proteins
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