FABP2

Fatty acid binding protein 2, intestinal, also known as FABP2, is a human gene.

PBB_Summary
section_title =
summary_text = The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.cite web | title = Entrez Gene: FABP2 fatty acid binding protein 2, intestinal| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2169| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kaikaus RM, Bass NM, Ockner RK |title=Functions of fatty acid binding proteins. |journal=Experientia |volume=46 |issue= 6 |pages= 617–30 |year= 1990 |pmid= 2193826 |doi=
*cite journal | author=Glatz JF, Luiken JJ, van Nieuwenhoven FA, Van der Vusse GJ |title=Molecular mechanism of cellular uptake and intracellular translocation of fatty acids. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=57 |issue= 1 |pages= 3–9 |year= 1997 |pmid= 9250601 |doi=
*cite journal | author=Storch J, Thumser AE |title=The fatty acid transport function of fatty acid-binding proteins. |journal=Biochim. Biophys. Acta |volume=1486 |issue= 1 |pages= 28–44 |year= 2000 |pmid= 10856711 |doi=
*cite journal | author=Edwards A, Hammond HA, Jin L, "et al." |title=Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. |journal=Genomics |volume=12 |issue= 2 |pages= 241–53 |year= 1992 |pmid= 1740333 |doi=
*cite journal | author=Polymeropoulos MH, Rath DS, Xiao H, Merril CR |title=Trinucleotide repeat polymorphism at the human intestinal fatty acid binding protein gene (FABP2). |journal=Nucleic Acids Res. |volume=18 |issue= 23 |pages= 7198 |year= 1991 |pmid= 2263509 |doi=
*cite journal | author=Sweetser DA, Birkenmeier EH, Klisak IJ, "et al." |title=The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships. |journal=J. Biol. Chem. |volume=262 |issue= 33 |pages= 16060–71 |year= 1987 |pmid= 2824476 |doi=
*cite journal | author=Lowe JB, Boguski MS, Sweetser DA, "et al." |title=Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins. |journal=J. Biol. Chem. |volume=260 |issue= 6 |pages= 3413–7 |year= 1985 |pmid= 3838313 |doi=
*cite journal | author=Baier LJ, Sacchettini JC, Knowler WC, "et al." |title=An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. |journal=J. Clin. Invest. |volume=95 |issue= 3 |pages= 1281–7 |year= 1995 |pmid= 7883976 |doi=
*cite journal | author=Goold RD, diSibio GL, Xu H, "et al." |title=The development of sequence-tagged sites for human chromosome 4. |journal=Hum. Mol. Genet. |volume=2 |issue= 8 |pages= 1271–88 |year= 1993 |pmid= 8401509 |doi=
*cite journal | author=Prochazka M, Lillioja S, Tait JF, "et al." |title=Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians. |journal=Diabetes |volume=42 |issue= 4 |pages= 514–9 |year= 1993 |pmid= 8454101 |doi=
*cite journal | author=Hegele RA, Harris SB, Hanley AJ, "et al." |title=Genetic variation of intestinal fatty acid-binding protein associated with variation in body mass in aboriginal Canadians. |journal=J. Clin. Endocrinol. Metab. |volume=81 |issue= 12 |pages= 4334–7 |year= 1997 |pmid= 8954037 |doi=
*cite journal | author=Zhang F, Lücke C, Baier LJ, "et al." |title=Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit. |journal=J. Biomol. NMR |volume=9 |issue= 3 |pages= 213–28 |year= 1997 |pmid= 9204553 |doi=
*cite journal | author=Darimont C, Gradoux N, Cumin F, "et al." |title=Differential regulation of intestinal and liver fatty acid-binding proteins in human intestinal cell line (Caco-2): role of collagen. |journal=Exp. Cell Res. |volume=244 |issue= 2 |pages= 441–7 |year= 1998 |pmid= 9806794 |doi= 10.1006/excr.1998.4186
*cite journal | author=Darimont C, Gradoux N, de Pover A |title=Epidermal growth factor regulates fatty acid uptake and metabolism in Caco-2 cells. |journal=Am. J. Physiol. |volume=276 |issue= 3 Pt 1 |pages= G606–12 |year= 1999 |pmid= 10070036 |doi=
*cite journal | author=Carlsson M, Orho-Melander M, Hedenbro J, "et al." |title=The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke. |journal=J. Clin. Endocrinol. Metab. |volume=85 |issue= 8 |pages= 2801–4 |year= 2000 |pmid= 10946885 |doi=
*cite journal | author=Chiu KC, Chuang LM, Yoon C |title=The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians. |journal=BMC Genet. |volume=2 |issue= |pages= 7 |year= 2003 |pmid= 11299043 |doi=
*cite journal | author=Makowski L, Boord JB, Maeda K, "et al." |title=Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. |journal=Nat. Med. |volume=7 |issue= 6 |pages= 699–705 |year= 2001 |pmid= 11385507 |doi= 10.1038/89076

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