IGFBP1

IGFBP1

Insulin-like growth factor binding protein 1, also known as IGFBP1, is a human gene.cite web | title = Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3484| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3484| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rajaram S, Baylink DJ, Mohan S |title=Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. |journal=Endocr. Rev. |volume=18 |issue= 6 |pages= 801–31 |year= 1998 |pmid= 9408744 |doi=
*cite journal | author=Ferry RJ, Cerri RW, Cohen P |title=Insulin-like growth factor binding proteins: new proteins, new functions. |journal=Horm. Res. |volume=51 |issue= 2 |pages= 53–67 |year= 1999 |pmid= 10352394 |doi=
*cite journal | author=Firth SM, Baxter RC |title=Cellular actions of the insulin-like growth factor binding proteins. |journal=Endocr. Rev. |volume=23 |issue= 6 |pages= 824–54 |year= 2003 |pmid= 12466191 |doi=
*cite journal | author=Wood AW, Duan C, Bern HA |title=Insulin-like growth factor signaling in fish. |journal=Int. Rev. Cytol. |volume=243 |issue= |pages= 215–85 |year= 2005 |pmid= 15797461 |doi= 10.1016/S0074-7696(05)43004-1
*cite journal | author=Ehrenborg E, Larsson C, Stern I, "et al." |title=Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7. |journal=Genomics |volume=12 |issue= 3 |pages= 497–502 |year= 1992 |pmid= 1373120 |doi=
*cite journal | author=Ekstrand J, Ehrenborg E, Stern I, "et al." |title=The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12. |journal=Genomics |volume=6 |issue= 3 |pages= 413–8 |year= 1990 |pmid= 1691735 |doi=
*cite journal | author=Suwanichkul A, Cubbage ML, Powell DR |title=The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1. |journal=J. Biol. Chem. |volume=265 |issue= 34 |pages= 21185–93 |year= 1991 |pmid= 1701175 |doi=
*cite journal | author=Brinkman A, Kortleve DJ, Schuller AG, "et al." |title=Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability. |journal=FEBS Lett. |volume=291 |issue= 2 |pages= 264–8 |year= 1991 |pmid= 1718783 |doi=
*cite journal | author=Brewer MT, Stetler GL, Squires CH, "et al." |title=Cloning, characterization, and expression of a human insulin-like growth factor binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=152 |issue= 3 |pages= 1289–97 |year= 1988 |pmid= 2454104 |doi=
*cite journal | author=Julkunen M, Koistinen R, Aalto-Setälä K, "et al." |title=Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA. |journal=FEBS Lett. |volume=236 |issue= 2 |pages= 295–302 |year= 1988 |pmid= 2457513 |doi=
*cite journal | author=Lee YL, Hintz RL, James PM, "et al." |title=Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors. |journal=Mol. Endocrinol. |volume=2 |issue= 5 |pages= 404–11 |year= 1988 |pmid= 2458522 |doi=
*cite journal | author=Brinkman A, Groffen C, Kortleve DJ, "et al." |title=Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1). |journal=EMBO J. |volume=7 |issue= 8 |pages= 2417–23 |year= 1989 |pmid= 2461294 |doi=
*cite journal | author=Luthman H, Söderling-Barros J, Persson B, "et al." |title=Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning. |journal=Eur. J. Biochem. |volume=180 |issue= 2 |pages= 259–65 |year= 1989 |pmid= 2466665 |doi=
*cite journal | author=Cubbage ML, Suwanichkul A, Powell DR |title=Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein. |journal=Mol. Endocrinol. |volume=3 |issue= 5 |pages= 846–51 |year= 1989 |pmid= 2474129 |doi=
*cite journal | author=Alitalo T, Kontula K, Koistinen R, "et al." |title=The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism. |journal=Hum. Genet. |volume=83 |issue= 4 |pages= 335–8 |year= 1989 |pmid= 2478445 |doi=
*cite journal | author=Brinkman A, Groffen CA, Kortleve DJ, Drop SL |title=Organization of the gene encoding the insulin-like growth factor binding protein IBP-1. |journal=Biochem. Biophys. Res. Commun. |volume=157 |issue= 3 |pages= 898–907 |year= 1989 |pmid= 2849945 |doi=
*cite journal | author=Busby WH, Klapper DG, Clemmons DR |title=Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions. |journal=J. Biol. Chem. |volume=263 |issue= 28 |pages= 14203–10 |year= 1988 |pmid= 2971653 |doi=
*cite journal | author=Grundmann U, Nerlich C, Bohn H, Rein T |title=Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin. |journal=Nucleic Acids Res. |volume=16 |issue= 17 |pages= 8711 |year= 1988 |pmid= 3419931 |doi=
*cite journal | author=Jones JI, Gockerman A, Busby WH, "et al." |title=Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 22 |pages= 10553–7 |year= 1993 |pmid= 7504269 |doi=
*cite journal | author=Jones JI, Busby WH, Wright G, "et al." |title=Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101. |journal=J. Biol. Chem. |volume=268 |issue= 2 |pages= 1125–31 |year= 1993 |pmid= 7678248 |doi=

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