IGFBP3

Insulin-like growth factor binding protein 3, also known as IGFBP3, is a human gene.

PBB_Summary
section_title =
summary_text = This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [cite web | title = Entrez Gene: IGFBP3 insulin-like growth factor binding protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3486| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rajaram S, Baylink DJ, Mohan S |title=Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. |journal=Endocr. Rev. |volume=18 |issue= 6 |pages= 801–31 |year= 1998 |pmid= 9408744 |doi=
*cite journal | author=Ferry RJ, Cerri RW, Cohen P |title=Insulin-like growth factor binding proteins: new proteins, new functions. |journal=Horm. Res. |volume=51 |issue= 2 |pages= 53–67 |year= 1999 |pmid= 10352394 |doi=
*cite journal | author=Schedlich LJ, Graham LD |title=Role of insulin-like growth factor binding protein-3 in breast cancer cell growth. |journal=Microsc. Res. Tech. |volume=59 |issue= 1 |pages= 12–22 |year= 2002 |pmid= 12242693 |doi= 10.1002/jemt.10173
*cite journal | author=Adham IM, Agoulnik AI |title=Insulin-like 3 signalling in testicular descent. |journal=Int. J. Androl. |volume=27 |issue= 5 |pages= 257–65 |year= 2005 |pmid= 15379965 |doi= 10.1111/j.1365-2605.2004.00481.x

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