- Androgen-binding protein
protein
Name = Androgen-binding protein, Sex hormone-binding globulin
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HGNCid = 10839
Symbol = SHBG
AltSymbols = ABP
EntrezGene = 6462
OMIM = 182205
RefSeq = NM_001040
UniProt = P04278
PDB =
ECnumber =
Chromosome = 17
Arm = p
Band = 13
LocusSupplementaryData = -p12Androgen-binding protein (ABP) is a
glycoprotein (beta-globulin ) produced by theSertoli cells in theseminiferous tubules of thetestis that binds specifically totestosterone (T),dihydrotestosterone (DHT), and 17-beta-estradiol .By binding to T and DHT these hormones are made less lipophilic and become concentrated within the luminal fluid of the seminiferous tubules. The higher levels of these hormones enable
spermatogenesis in theseminiferous tubules and sperm maturation in theepididymis .ABP has the same
amino acid sequence assex hormone-binding globulin (SHBG ); the difference is the site of production and the addition of different sugar moieties. ABP contains 403 amino acids resulting in amolecular weight of 44,533. Its gene is located onchromosome 17 .ABP’s production is regulated under influence of
FSH on Sertoli cell, enhanced byinsulin ,retinol , andtestosterone .ABP may also be secreted in other organs, for instance mice produce a
saliva ry ABP.See also
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SHBG References
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External links
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