- Monocytosis
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Monocytosis Classification and external resources ICD-10 D72.8 ICD-9 288.8 DiseasesDB 22713 Monocytosis is an increase in the number of monocytes circulating in the blood.[1] Monocytes are white blood cells that give rise to macrophages and dendritic cells in the immune system.
In humans, 950/μL is regarded as at the upper limit of normal; monocyte counts above this level are regarded as monocytosis.[citation needed]
Causes
Monocytosis often occurs during chronic inflammation. Diseases that produce this state:
- Infections: tuberculosis, brucellosis, listeriosis, subacute bacterial endocarditis, syphilis, and other viral infections and many protozoal and rickettsial infections (e.g. kala azar, malaria, Rocky Mountain spotted fever).
- Blood and immune causes: chronic neutropenia and myeloproliferative disorders.
- Autoimmune diseases and vasculitis: systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease.
- Malignancies: Hodgkin's disease and certain leukaemias, such as chronic myelomonocytic leukaemia (CMML) and monocytic leukemia.
- Recovery phase of neutropenia or an acute infection.
- Miscellaneous causes: sarcoidosis and lipid storage disease.
References
- ^ "monocytosis" at Dorland's Medical Dictionary
Hematologic disease: Monocyte and granulocyte disease (CFU-GM/CFU-Baso/CFU-Eos), including immunodeficiency (D70-D71, 288) Monocytes/
macrophages↑↓Granulocytes ↑↓PBD This medical sign article is a stub. You can help Wikipedia by expanding it.