Phenylacetone

Phenylacetone
IUPAC name 1-phenylpropan-2-one
Other names benzyl methyl ketone; methyl benzyl ketone; phenyl-2-propanone
Identifiers
CAS number	103-79-7 Y
ChemSpider	21106366 Y
UNII	O7IZH10V9Y Y
KEGG	C15512 Y
ChEBI	CHEBI:52052 Y
Jmol-3D images	Image 1
SMILES O=C(C)Cc1ccccc1
InChI InChI=1S/C9H10O/c1-8(10)7-9-5-3-2-4-6-9/h2-6H,7H2,1H3 Y Key: QCCDLTOVEPVEJK-UHFFFAOYSA-N Y InChI=1/C9H10O/c1-8(10)7-9-5-3-2-4-6-9/h2-6H,7H2,1H3 Key: QCCDLTOVEPVEJK-UHFFFAOYAG
Properties
Molecular formula	C9H10O
Molar mass	134.18 g mol−1
Density	1.006 g/mL
Melting point	-15 °C
Boiling point	214 — 216 °C
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Phenylacetone (known also as phenyl-2-propanone, benzyl methyl ketone, or methyl benzyl ketone), is an organic compound. It is a clear oil with a refractive index of 1.5168. This substance is used in the manufacture of methamphetamine and amphetamine as a starting material or intermediate, where it is commonly known as P2P. Due to the illicit uses in clandestine chemistry, it was declared a schedule II controlled substance in the United States 11. February 1980.^[1]

Preparation

There are many methods in the scientific literature to prepare phenylacetone, and due to its status as a controlled substance, there is crossover into popular literature such as works by Uncle Fester and Alexander Shulgin. Large amounts of data are available on the Internet relating to the preparation of phenylacetone.

A conceptually simple example of phenylacetone organic synthesis is the Friedel-Crafts alkylation of benzene with chloroacetone.

Phenylacetone can also be produced from many other compounds. For example:

• phenylacetic acid is distilled with lead acetate or calcium acetate to yield phenylacetone.
• benzaldehyde is reacted with nitroethane yielding phenyl-2-nitropropene, which is reduced, usually in the presence of acid, to phenylacetone.

Phenyl acetone is used as an intermediate to produce pesticides and anticoagulants. Active ingredients as anticoagulant include:

• Brodifacoum
• Chlorophacinone
• Coumachlor
• Difenacoum
• Diphacinane
• 2-Pivaloyl-1,3-indandione
• 2-Isovaleryl-1,3-indandione
• Warfarin

See also

• MDP2P - related compound with a methylenedioxy group, and a precursor to MDMA.

References

1. ^ http://isomerdesign.com/Cdsa/scheduleUS.php?schedule=2&section=6&structure=U&structure=C