DPEP3

Dipeptidase 3
Identifiers
Symbols	DPEP3; MBD3
External IDs	OMIM: 609926 MGI: 1919104 HomoloGene: 23357 GeneCards: DPEP3 Gene
EC number	3.4.13.19
Gene Ontology Molecular function • peptidase activity • metalloexopeptidase activity • dipeptidyl-peptidase activity • dipeptidase activity • metal ion binding Cellular component • membrane fraction • membrane • anchored to membrane Biological process • proteolysis • meiosis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64180	71854
Ensembl	ENSG00000141096	ENSMUSG00000031898
UniProt	Q9H4B8	Q9DA79
RefSeq (mRNA)	NM_001129758.1	NM_027960.2
RefSeq (protein)	NP_001123230.1	NP_082236.1
Location (UCSC)	Chr 16: 68.01 – 68.01 Mb	Chr 8: 108.5 – 108.5 Mb
PubMed search	[1]	[2]

Dipeptidase 3 (DPEP3) is a protein that in humans is encoded by the DPEP3 gene.^[1]

This gene encodes a membrane-bound glycoprotein from the family of dipeptidases (EC 3.4.13.19) involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family, DPEP2. Alternatively spliced transcript variants that encode different isoforms have been found for this gene.^[2]

References

1. ^ Habib GM, Shi ZZ, Cuevas AA, Lieberman MW (July 2003). "Identification of two additional members of the membrane-bound dipeptidase family". The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17 (10): 1313–5. doi:10.1096/fj.02-0899fje. PMID 12738806. 
2. ^ "Entrez Gene: Dipeptidase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64180. 

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Sabatti C, Service SK, Hartikainen AL, et al. (2009). "Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.". Nat. Genet. 41 (1): 35–46. doi:10.1038/ng.271. PMC 2687077. PMID 19060910. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2687077. 
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.