- DPEP3
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Dipeptidase 3 Identifiers Symbols DPEP3; MBD3 External IDs OMIM: 609926 MGI: 1919104 HomoloGene: 23357 GeneCards: DPEP3 Gene EC number 3.4.13.19 Gene Ontology Molecular function • peptidase activity
• metalloexopeptidase activity
• dipeptidyl-peptidase activity
• dipeptidase activity
• metal ion bindingCellular component • membrane fraction
• membrane
• anchored to membraneBiological process • proteolysis
• meiosisSources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 64180 71854 Ensembl ENSG00000141096 ENSMUSG00000031898 UniProt Q9H4B8 Q9DA79 RefSeq (mRNA) NM_001129758.1 NM_027960.2 RefSeq (protein) NP_001123230.1 NP_082236.1 Location (UCSC) Chr 16:
68.01 – 68.01 MbChr 8:
108.5 – 108.5 MbPubMed search [1] [2] Dipeptidase 3 (DPEP3) is a protein that in humans is encoded by the DPEP3 gene.[1]
This gene encodes a membrane-bound glycoprotein from the family of dipeptidases (EC 3.4.13.19) involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family, DPEP2. Alternatively spliced transcript variants that encode different isoforms have been found for this gene.[2]
References
- ^ Habib GM, Shi ZZ, Cuevas AA, Lieberman MW (July 2003). "Identification of two additional members of the membrane-bound dipeptidase family". The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17 (10): 1313–5. doi:10.1096/fj.02-0899fje. PMID 12738806.
- ^ "Entrez Gene: Dipeptidase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64180.
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Sabatti C, Service SK, Hartikainen AL, et al. (2009). "Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.". Nat. Genet. 41 (1): 35–46. doi:10.1038/ng.271. PMC 2687077. PMID 19060910. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2687077.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Hydrolase: proteases (EC 3.4) 3.4.11-19: Exopeptidase Dipeptidyl peptidase (Cathepsin C, Dipeptidyl peptidase-4) · Tripeptidyl peptidase (Tripeptidyl peptidase I, Tripeptidyl peptidase II)Other/ungrouped3.4.21-24: Endopeptidase Serine proteases · Cysteine protease · Aspartic acid protease · Metalloendopeptidases
Other/ungrouped: Amyloid precursor protein secretase (Alpha secretase, Beta-secretase 1, Beta-secretase 2, Gamma secretase)3.4.99: Unknown B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6 Categories:- Human proteins
- Chromosome 16 gene stubs
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