Dipeptidase 1

Dipeptidase 1
Dipeptidase 1 (renal)

PDB rendering based on 1itq.
Symbols DPEP1; MBD1; MDP; RDP
External IDs OMIM179780 MGI94917 HomoloGene80192 GeneCards: DPEP1 Gene
EC number
RNA expression pattern
PBB GE DPEP1 205983 at tn.png
More reference expression data
Species Human Mouse
Entrez 1800 13479
Ensembl ENSG00000015413 ENSMUSG00000019278
UniProt P16444 Q3V175
RefSeq (mRNA) NM_001128141.1 NM_007876.2
RefSeq (protein) NP_001121613.1 NP_031902.2
Location (UCSC) Chr 16:
89.68 – 89.7 Mb
Chr 8:
125.71 – 125.73 Mb
PubMed search [1] [2]

Dipeptidase 1 is an enzyme that in humans is encoded by the DPEP1 gene.[1]

DPEP1 (EC is a kidney membrane enzyme that hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates, e.g., leukotriene D4 (Kozak and Tate, 1982). DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics, such as penem and carbapenem (Campbell et al., 1984). Earlier, beta-lactamase enzymes were thought to occur only in bacteria, where their probable function was in protecting the organisms against the action of beta-lactam antibiotics. These antibiotics exhibit selective toxicity against bacteria but virtual inertness against many eukaryotic cells (Adachi et al., 1990).[supplied by OMIM][1]


Dipeptidase 1 has been shown to interact with KIAA1279.[2]


  1. ^ a b "Entrez Gene: DPEP1 dipeptidase 1 (renal)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1800. 
  2. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

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Look at other dictionaries:

  • dipeptidase — noun Date: 1927 any of various enzymes that hydrolyze dipeptides but not polypeptides …   New Collegiate Dictionary

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  • Dipeptidase — Dipeptidasen sind Enzyme, die Dipeptide hydrolytisch in zwei Aminosäuren spalten. Dipeptidasen bilden damit eine Untergruppe der Peptidasen. Dipeptidasen kommen vor allem im Verdauungstrakt der Tiere vor, wo sie die abschließenden… …   Deutsch Wikipedia

  • dipeptidase — /duy pep ti days , dayz /, n. Biochem. any enzyme that catalyzes the hydrolysis of dipeptides. [DIPEPTIDE + ASE] * * * …   Universalium

  • dipeptidase — noun Any of a class of enzymes that hydrolyze dipeptides in the small intestine …   Wiktionary

  • dipeptidase — A hydrolase catalyzing the hydrolysis of a dipeptide to its constituent amino acid s. methionyl d. a hydrolase catalyzing the hydrolysis of an l methionyl amino acid to l methionine and an amino acid. * * * di·pep·ti·dase dī pep tə .dās, .dāz n… …   Medical dictionary

  • Dipeptidase — Di|pep|ti|da|se [↑ Dipeptid u. ↑ ase], die; , n; Syn.: Dipeptid Hydrolase: eine ↑ Peptidase, die Dipeptide in Aminosäuren zerlegt. * * * Di|pep|ti|da|se, die; , n (Chemie): Enzym, das Dipeptide spaltet …   Universal-Lexikon

  • Dipeptidase — Di|pep|ti|da|se 〈f.; Gen.: , Pl.: n; Chemie〉 Enzym, das Dipeptide spaltet [Etym.: <Di…2 + Peptidase] …   Lexikalische Deutsches Wörterbuch

  • Dipeptidase — Di|peptida̱se [↑...ase] w; , n: Enzym, das Dipeptide spaltet …   Das Wörterbuch medizinischer Fachausdrücke

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