Combretastatin A-4

Combretastatin A-4
IUPAC name 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol
Other names Combretastatin A4 CA-4
Identifiers
CAS number	117048-59-6 N
PubChem	5351344
ChemSpider	4508364 Y
ChEMBL	CHEMBL67 Y
Jmol-3D images	Image 1
SMILES COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O
InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5- Y Key: HVXBOLULGPECHP-WAYWQWQTSA-N Y
Properties
Molecular formula	C18H20O5
Molar mass	316.34 g/mol
Exact mass	316.131074 u
Melting point	116 °C[1]
N A-4 (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Combretastatin A-4 is a combretastatin, a type of stilbenoid. It can be isolated from Combretum caffrum, the Eastern Cape South African Bushwillow tree.

Derivatives

Combretastatin A-4 is the active component of combretastatin A-4 phosphate, a prodrug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.

See also

• Ombrabulin, a combretastatin A-4 derivative in clinical trials for treatment of cancer

References

1. ^ Pettit, G. R. Sheo Bux Singh Boyd, M. R. Hamel, E. (1995), "Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6", Journal of Medicinal Chemistry 38: 1666–1672, doi:10.1021/jm00010a011 

This article about a natural phenol is a stub. You can help Wikipedia by expanding it.v · Categories: Stilbenoids Natural phenol stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Combretastatin A-1 Combretastatin A-4 phosphate Look at other dictionaries: Combretastatin — IUPAC name 5 [(2R) 2 hydroxy 2 (3,4,5 trimethoxyphenyl)ethyl] 2 methoxyphenol …   Wikipedia Combretastatin A-1 — IUPAC name 3 Methoxy 6 [(E) 2 (3,4,5 trimethoxyphenyl)ethenyl]benzene 1,2 diol …   Wikipedia Combretastatin A-4 phosphate — Systematic (IUPAC) name Phosphoric acid mono {2 methoxy 5 [(Z) 2 (3,4,5 trimethoxy phenyl) vinyl] phenyl} ester Clinical data …   Wikipedia Combretastatin — Combretastatˈin® noun A drug derived from the African bush willow tree, used as an experimental treatment for cancer • • • Main Entry: ↑combretum …   Useful english dictionary Combretastatin® — Combretastatˈin® noun A drug derived from the African bush willow tree, used as an experimental treatment for cancer ● combretum …   Useful english dictionary combretastatin A4 phosphate — A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called tubulin binding agents …   English dictionary of cancer terms Discovery and development of tubulin inhibitors — Tubulin inhibitors interfere directly with the tubulin system which is in contrast to those drugs acting on DNA for cancer chemotherapy. Microtubules play an important role in eukaryotic cells. Alpha and beta tubulin, the main components of… …   Wikipedia alpha-Viniferin — α Viniferin Other names α Viniferin; (+) α Viniferin Identifiers …   Wikipedia epsilon-Viniferin — ε Viniferin IUPAC name 5 [(2R,3R) 6 Hydroxy 2 (4 hydroxyphenyl) 4 [(E) 2 (4 hydroxyphenyl)ethenyl] 2,3 dihydro 1 b …   Wikipedia Viniferal — IUPAC name (2R,2′S,3R,3′S) 3′ (3,5 Dihydroxyphenyl) 6′ hydroxy 2,2′ bis(4 hydroxyp …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”