Piceatannol

Chembox new
Reference= [ [http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIGMA/P0453 Piceatannol] at Sigma-Aldrich]
ImageFile=Piceatannol.pngImageSize=200px
IUPACName=5- [(E)-2-(3,4-dihydroxyphenyl)vinyl] benzene-1,3-diol
OtherNames=3,4,3',5'-tetrahydroxy-"trans"-stilbene
Section1= Chembox Identifiers
CASNo=10083-24-6
PubChem=667639
SMILES=C1=CC(=C(C=C1C=CC2=CC(=CC(=C2)O)O)O)O
Section2= Chembox Properties
Formula=C₁₄H₁₂O₄
MolarMass=244.24
Appearance=Light tan to yellow powder
Density=
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Section3= Chembox Hazards
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Piceatannol (3,4,3',5'-tetrahydroxy-"trans"-stilbene) is a phenolic stilbenoid. It is a metabolite of resveratrol found in red wine. LMP2A, a viral protein-tyrosine kinase implicated in leukemia, non-Hodgkin's lymphoma and other diseases associated with Epstein-Barr virus, were found to be blocked by picetannol "in vitro". [cite journal |author=Geahlen RL, McLaughlin JL |title=Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor |journal=Biochem. Biophys. Res. Commun. |volume=165 |issue=1 |pages=241–5 |year=1989 |pmid=2590224 |doi=] Therefore there is research interest in piceatannol as an anti-cancer and anti-EBV drug. [cite journal |author=Swanson-Mungerson M, Ikeda M, Lev L, Longnecker R, Portis T |title=Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein-Barr virus (EBV)-associated diseases |journal=J. Antimicrob. Chemother. |volume=52 |issue=2 |pages=152–4 |year=2003 |pmid=12837743 |doi=10.1093/jac/dkg306]

ee also

* Pterostilbene
* List of phytochemicals and foods in which they are prominent

References