Combretastatin A-1

Combretastatin A-1
IUPAC name 3-Methoxy-6-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzene-1,2-diol
Other names Combretastatin A1
Identifiers
CAS number	109971-63-3 N
PubChem	6078282
ChemSpider	4800178 Y
ChEMBL	CHEMBL520204 Y
Jmol-3D images	Image 1
SMILES COC1=C(C(=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O)O
InChI InChI=1S/C18H20O6/c1-21-13-8-7-12(16(19)17(13)20)6-5-11-9-14(22-2)18(24-4)15(10-11)23-3/h5-10,19-20H,1-4H3/b6-5+ Y Key: YUSYSJSHVJULID-AATRIKPKSA-N Y
Properties
Molecular formula	C18H20O6
Molar mass	332.35 g mol−1
Exact mass	332.125988
N A-1 (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Combretastatin A-1 is a combretastatin, a chemical compound belonging to stilbenoid class. It can be found in Combretum caffrum, the Eastern Cape South African Bushwillow tree.^[1]

It is an antiangiogenic agent acting by destabilizing tubulin, which induces cell apoptosis of proliferating endothelial cells.^[1]

References

1. ^ ^{a b} Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum. Pettit G R, Singh S B, Niven M L, Hamel E and Schmidt J M, J-Nat-Prod. 1987 Jan-Feb; 50(1): 119-31, PubMed, doi:10.1021/np50049a016

This article about a natural phenol is a stub. You can help Wikipedia by expanding it.v · Categories: Stilbenoids Natural phenol stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Combresomyces Combretastatin A-4 Look at other dictionaries: Combretastatin — IUPAC name 5 [(2R) 2 hydroxy 2 (3,4,5 trimethoxyphenyl)ethyl] 2 methoxyphenol …   Wikipedia Combretastatin A-4 — IUPAC name 2 Methoxy 5 [(Z) 2 (3,4,5 trimethoxy phenyl) vinyl] phenol …   Wikipedia Combretastatin A-4 phosphate — Systematic (IUPAC) name Phosphoric acid mono {2 methoxy 5 [(Z) 2 (3,4,5 trimethoxy phenyl) vinyl] phenyl} ester Clinical data …   Wikipedia Combretastatin — Combretastatˈin® noun A drug derived from the African bush willow tree, used as an experimental treatment for cancer • • • Main Entry: ↑combretum …   Useful english dictionary Combretastatin® — Combretastatˈin® noun A drug derived from the African bush willow tree, used as an experimental treatment for cancer ● combretum …   Useful english dictionary combretastatin A4 phosphate — A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called tubulin binding agents …   English dictionary of cancer terms Discovery and development of tubulin inhibitors — Tubulin inhibitors interfere directly with the tubulin system which is in contrast to those drugs acting on DNA for cancer chemotherapy. Microtubules play an important role in eukaryotic cells. Alpha and beta tubulin, the main components of… …   Wikipedia alpha-Viniferin — α Viniferin Other names α Viniferin; (+) α Viniferin Identifiers …   Wikipedia epsilon-Viniferin — ε Viniferin IUPAC name 5 [(2R,3R) 6 Hydroxy 2 (4 hydroxyphenyl) 4 [(E) 2 (4 hydroxyphenyl)ethenyl] 2,3 dihydro 1 b …   Wikipedia Viniferal — IUPAC name (2R,2′S,3R,3′S) 3′ (3,5 Dihydroxyphenyl) 6′ hydroxy 2,2′ bis(4 hydroxyp …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”