Combretastatin A-4 phosphate

Combretastatin A-4 phosphate

Systematic (IUPAC) name
Phosphoric acid mono-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenyl} ester
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	?
PubChem	CID 5351387
Synonyms	CA4P CA4PD
Chemical data
Formula	C18H21O8P
Mol. mass	396.32 g/mol (exact mass : 396.097404)
Y(what is this?)  A-4 phosphate (verify)

For more information about this drug and its actions, see combretastatin.

Combretastatin A-4 phosphate (and its disodium salt) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. It is a derivative of combretastatin.

Combretastatin A-4 phosphate is a prodrug. In vivo, it is dephosphorylated to its active metabolite, combretastatin A-4.^[1]

References

1. ^ Combretastatin A-4 phosphate on www.cancer.gov

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Prodrugs Antineoplastic and immunomodulating drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Combretastatin A-4 Combretol Look at other dictionaries: Combretastatin — IUPAC name 5 [(2R) 2 hydroxy 2 (3,4,5 trimethoxyphenyl)ethyl] 2 methoxyphenol …   Wikipedia Combretastatin A-4 — IUPAC name 2 Methoxy 5 [(Z) 2 (3,4,5 trimethoxy phenyl) vinyl] phenol …   Wikipedia combretastatin A4 phosphate — A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called tubulin binding agents …   English dictionary of cancer terms List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * …   Wikipedia Athymische Maus — Eine Nacktmaus …   Deutsch Wikipedia Nacktmaus — Eine Nacktmaus …   Deutsch Wikipedia Thymusaplastische Maus — Eine Nacktmaus …   Deutsch Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”