Chalconoid

Chalcone, the structural backbone of chalconoids

Chalconoids, also known as chalcones, are natural phenols related to chalcone. They form the central core for a variety of important biological compounds. They show antibacterial, antifungal, antitumor and anti-inflammatory properties. Some chalconoids demonstrated the ability to block voltage-dependent potassium channels.^[1] They are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities. Chalconoids are also intermediates in the Auwers synthesis of flavones.

Biosynthesis and metabolism

Chalcone synthase is an enzyme responsible for the production of chalconoids in plants.
Chalcone isomerase is responsible for their conversion into flavanones and other flavonoids.
Naringenin-chalcone synthase uses malonyl-CoA and 4-coumaroyl-CoA to produce CoA, naringenin chalcone, and CO₂.
In aurones, the chalcone-like structure closes into a 5-atom ring instead of the more typical 6-atom ring (C ring).

Related compounds

• Dihydrochalcones

See also

• Phytonutrients

References

1. ^ Yarishkin, O. V.; Ryu, H. W.; Park, J. Y.; Yang, M. S.; Hong, S. G.; Park, K. H. (2008). "Sulfonate chalcone as new class voltage-dependent K+ channel blocker". Bioorganic & Medicinal Chemistry Letters 18 (1): 137–140. doi:10.1016/j.bmcl.2007.10.114. PMID 18032041.  edit

External links

• "Chalcones". Reference.MD. http://www.reference.md/files/D047/mD047188.html.