DCP1B

DCP1 decapping enzyme homolog B (S. cerevisiae)
Identifiers
Symbols	DCP1B; DCP1; hDcp1b
External IDs	OMIM: 609843 MGI: 2442404 HomoloGene: 51881 GeneCards: DCP1B Gene
Gene Ontology Molecular function • protein binding • hydrolase activity Cellular component • nucleus • cytoplasm • cytosol Biological process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • RNA metabolic process • mRNA metabolic process • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	196513	319618
Ensembl	ENSG00000151065	ENSMUSG00000041477
UniProt	Q8IZD4	n/a
RefSeq (mRNA)	NM_152640	NM_001033379.3
RefSeq (protein)	NP_689853	NP_001028551.2
Location (UCSC)	Chr 12: 2.06 – 2.11 Mb	Chr 6: 119.13 – 119.17 Mb
PubMed search	[1]	[2]

mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene.^[1][2][3]

DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002).[supplied by OMIM]^[3]

References

1. ^ Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=134073. 
2. ^ Cougot N, Babajko S, Seraphin B (Apr 2004). "Cytoplasmic foci are sites of mRNA decay in human cells". J Cell Biol 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC 2172085. PMID 15067023. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172085. 
3. ^ ^{a b} "Entrez Gene: DCP1B DCP1 decapping enzyme homolog B (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=196513. 

Further reading

• Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
• Rush J, Moritz A, Lee KA et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.