Major vault protein

Major vault protein
PDB rendering based on 1y7x.
Available structures PDB 1y7x
Identifiers
Symbols	MVP; LRP; VAULT1
External IDs	OMIM: 605088 MGI: 1925638 HomoloGene: 3752 GeneCards: MVP Gene
Gene Ontology Molecular function • protein binding Cellular component • nucleus • nuclear pore • cytoplasm • ribonucleoprotein complex • intracellular membrane-bounded organelle Biological process • protein transport • response to drug • mRNA transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9961	78388
Ensembl	ENSG00000013364	ENSMUSG00000030681
UniProt	Q14764	Q3THX5
RefSeq (mRNA)	NM_005115.4	NM_080638.3
RefSeq (protein)	NP_005106.2	NP_542369.2
Location (UCSC)	Chr 16: 29.83 – 29.86 Mb	Chr 7: 134.13 – 134.16 Mb
PubMed search	[1]	[2]

Major vault protein is a protein that in humans is encoded by the MVP gene.^[1][2]

This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.^[2]

Interactions

Major vault protein has been shown to interact with Estrogen receptor alpha,^[3] PTEN^[4] and PARP4.^[5][6]

References

1. ^ Scheffer GL, Wijngaard PL, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJ, Clevers HC, Scheper RJ (Dec 1995). "The drug resistance-related protein LRP is the human major vault protein". Nat Med 1 (6): 578–82. doi:10.1038/nm0695-578. PMID 7585126. 
2. ^ ^{a b} "Entrez Gene: MVP major vault protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9961. 
3. ^ Abbondanza, C; Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari A M, Moncharmont B, Puca G A (Jun. 1998). "Interaction of Vault Particles with Estrogen Receptor in the MCF-7 Breast Cancer Cell". J. Cell Biol. (UNITED STATES) 141 (6): 1301–10. doi:10.1083/jcb.141.6.1301. ISSN 0021-9525. PMC 2132791. PMID 9628887. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132791. 
4. ^ Yu, Zhenbao; Fotouhi-Ardakani Nasser, Wu Liangtang, Maoui Meryem, Wang Shenglong, Banville Denis, Shen Shi-Hsiang (Oct. 2002). "PTEN associates with the vault particles in HeLa cells". J. Biol. Chem. (United States) 277 (43): 40247–52. doi:10.1074/jbc.M207608200. ISSN 0021-9258. PMID 12177006. 
5. ^ van Zon, Arend; Mossink Marieke H, Schoester Martijn, Scheffer George L, Scheper Rik J, Sonneveld Pieter, Wiemer Erik A C (Mar. 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. (United States) 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. ISSN 0006-291X. PMID 11855821. 
6. ^ Kickhoefer, V A; Siva A C, Kedersha N L, Inman E M, Ruland C, Streuli M, Rome L H (Sep. 1999). "The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase". J. Cell Biol. (UNITED STATES) 146 (5): 917–28. doi:10.1083/jcb.146.5.917. ISSN 0021-9525. PMC 2169495. PMID 10477748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169495. 

Further reading

• Izquierdo MA, Scheffer GL, Flens MJ, et al. (1996). "Major vault protein LRP-related multidrug resistance". Eur. J. Cancer 32A (6): 979–84. doi:10.1016/0959-8049(96)00053-6. PMID 8763338. 
• Slovak ML, Ho JP, Cole SP, et al. (1995). "The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification". Cancer Res. 55 (19): 4214–9. PMID 7671223. 
• Izquierdo MA, Scheffer GL, Flens MJ, et al. (1997). "Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors". Am. J. Pathol. 148 (3): 877–87. PMC 1861735. PMID 8774142. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1861735. 
• Dingemans AM, van Ark-Otte J, van der Valk P, et al. (1997). "Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues". Ann. Oncol. 7 (6): 625–30. PMID 8879378. 
• Sugawara I, Akiyama S, Scheper RJ, Itoyama S (1997). "Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP". Cancer Lett. 112 (1): 23–31. doi:10.1016/S0304-3835(96)04542-9. PMID 9029166. 
• Abbondanza C, Rossi V, Roscigno A, et al. (1998). "Interaction of Vault Particles with Estrogen Receptor in the MCF-7 Breast Cancer Cell". J. Cell Biol. 141 (6): 1301–10. doi:10.1083/jcb.141.6.1301. PMC 2132791. PMID 9628887. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132791. 
• Ikeda K, Oka M, Yamada Y, et al.; Oka (1999). "Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes". Int. J. Cancer 82 (4): 599–604. doi:10.1002/(SICI)1097-0215(19990812)82:4<599::AID-IJC21>3.0.CO;2-R. PMID 10404077. 
• Rimsza LM, Campbell K, Dalton WS, et al. (1999). "The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma". Leuk. Lymphoma 34 (3–4): 315–24. doi:10.3109/10428199909050956. PMID 10439368. 
• Kickhoefer VA, Siva AC, Kedersha NL, et al. (1999). "The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase". J. Cell Biol. 146 (5): 917–28. doi:10.1083/jcb.146.5.917. PMC 2169495. PMID 10477748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169495. 
• Kickhoefer VA, Stephen AG, Harrington L, et al. (2000). "Vaults and telomerase share a common subunit, TEP1". J. Biol. Chem. 274 (46): 32712–7. doi:10.1074/jbc.274.46.32712. PMID 10551828. 
• Lange C, Walther W, Schwabe H, Stein U (2001). "Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter". Biochem. Biophys. Res. Commun. 278 (1): 125–33. doi:10.1006/bbrc.2000.3782. PMID 11071864. 
• Holzmann K, Ambrosch I, Elbling L, et al. (2001). "A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant". FEBS Lett. 494 (1–2): 99–104. doi:10.1016/S0014-5793(01)02318-3. PMID 11297743. 
• van Zon A, Mossink MH, Schoester M, et al. (2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. PMID 11855821. 
• Sakaki Y, Terashi K, Yamaguchi A, et al. (2002). "Human T-cell lymphotropic virus type I Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient". Exp. Hematol. 30 (4): 340–5. doi:10.1016/S0301-472X(02)00775-0. PMID 11937269. 
• Zhao Y, Yu L, Wang Q, et al. (2002). "[The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia]". Zhonghua Nei Ke Za Zhi 41 (3): 183–5. PMID 11940320. 
• Scheffer GL, Pijnenborg AC, Smit EF, et al. (2002). "Multidrug resistance related molecules in human and murine lung". J. Clin. Pathol. 55 (5): 332–9. doi:10.1136/jcp.55.5.332. PMC 1769658. PMID 11986335. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1769658. 
• van den Heuvel-Eibrink MM, Wiemer EA, Prins A, et al. (2002). "Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)". Leukemia 16 (5): 833–9. doi:10.1038/sj.leu.2402496. PMID 11986944. 
• Yu Z, Fotouhi-Ardakani N, Wu L, et al. (2002). "PTEN associates with the vault particles in HeLa cells". J. Biol. Chem. 277 (43): 40247–52. doi:10.1074/jbc.M207608200. PMID 12177006.