HNRNPL

Heterogeneous nuclear ribonucleoprotein L, also known as HNRPL, is a human gene.cite web | title = Entrez Gene: HNRPL heterogeneous nuclear ribonucleoprotein L| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3191| accessdate = ]

PBB_Summary
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summary_text = Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: HNRPL heterogeneous nuclear ribonucleoprotein L| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3191| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dreyfuss G, Choi YD, Adam SA |title=The ribonucleoprotein structures along the pathway of mRNA formation. |journal=Endocr. Res. |volume=15 |issue= 4 |pages= 441–74 |year= 1990 |pmid= 2576798 |doi=
*cite journal | author=Rasmussen HH, van Damme J, Puype M, "et al." |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=
*cite journal | author=Piñol-Roma S, Swanson MS, Gall JG, Dreyfuss G |title=A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts. |journal=J. Cell Biol. |volume=109 |issue= 6 Pt 1 |pages= 2575–87 |year= 1990 |pmid= 2687284 |doi=
*cite journal | author=Hahm B, Cho OH, Kim JE, "et al." |title=Polypyrimidine tract-binding protein interacts with HnRNP L. |journal=FEBS Lett. |volume=425 |issue= 3 |pages= 401–6 |year= 1998 |pmid= 9563502 |doi=
*cite journal | author=Shih SC, Claffey KP |title=Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L. |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1359–65 |year= 1999 |pmid= 9880507 |doi=
*cite journal | author=Hamilton BJ, Nichols RC, Tsukamoto H, "et al." |title=hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo. |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 646–51 |year= 1999 |pmid= 10441480 |doi= 10.1006/bbrc.1999.1040
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Kim JH, Hahm B, Kim YK, "et al." |title=Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm. |journal=J. Mol. Biol. |volume=298 |issue= 3 |pages= 395–405 |year= 2000 |pmid= 10772858 |doi= 10.1006/jmbi.2000.3687
*cite journal | author=Shnyreva M, Schullery DS, Suzuki H, "et al." |title=Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15498–503 |year= 2000 |pmid= 10809782 |doi=
*cite journal | author=Ito M, Shichijo S, Tsuda N, "et al." |title=Molecular basis of T cell-mediated recognition of pancreatic cancer cells. |journal=Cancer Res. |volume=61 |issue= 5 |pages= 2038–46 |year= 2001 |pmid= 11280764 |doi=
*cite journal | author=Kuninger DT, Izumi T, Papaconstantinou J, Mitra S |title=Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. |journal=Nucleic Acids Res. |volume=30 |issue= 3 |pages= 823–9 |year= 2002 |pmid= 11809897 |doi=
*cite journal | author=Söderberg M, Raffalli-Mathieu F, Lang MA |title=Inflammation modulates the interaction of heterogeneous nuclear ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA. |journal=Mol. Pharmacol. |volume=62 |issue= 2 |pages= 423–31 |year= 2002 |pmid= 12130696 |doi=
*cite journal | author=Hui J, Stangl K, Lane WS, Bindereif A |title=HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. |journal=Nat. Struct. Biol. |volume=10 |issue= 1 |pages= 33–7 |year= 2007 |pmid= 12447348 |doi= 10.1038/nsb875
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Costain WJ, Mishra RK |title=PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex: identification by ddPCR. |journal=Peptides |volume=24 |issue= 1 |pages= 137–46 |year= 2003 |pmid= 12576095 |doi=
*cite journal | author=Hui J, Reither G, Bindereif A |title=Novel functional role of CA repeats and hnRNP L in RNA stability. |journal=RNA |volume=9 |issue= 8 |pages= 931–6 |year= 2003 |pmid= 12869704 |doi=
*cite journal | author=Gulesserian T, Engidawork E, Fountoulakis M, Lubec G |title=Decreased brain levels of Lupus La protein and increased U5 small ribonucleoprotein-specific 40 kDa protein in fetal Down syndrome. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=49 |issue= 5 |pages= 733–8 |year= 2004 |pmid= 14528909 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Cheng J, Kapranov P, Drenkow J, "et al." |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. |journal=Science |volume=308 |issue= 5725 |pages= 1149–54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625

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