Ribonucleoprotein (RNP) is a
nucleoproteinthat contains RNA, i.e. it is an association that combines ribonucleic acidand proteintogether. A few examples are known like the ribosome, the enzyme telomeraseand small nuclear RNPs (snRNPs) which are implicated in pre-mRNA splicingand are among the main components of the nucleolus.
RNP in snRNPs has an RNA-binding motif in its RNA-binding protein. Aromatic
amino acidresidues in this motif result in stacking interactions with RNA. Lysineresidues in the helical portion of RNA-binding proteins help to stabilize interactions with nucleic acids. This nucleic acid binding is strengthened by electrostatic attraction between the positive lysine side chains and the negative nucleic acid phosphatebackbones.
Anti-RNP antibodies are associated with "
mixed connective tissue disease" and are also detected in nearly 40% of Lupus erythematosuspatients. Two types of anti-RNP antibodies are closely related to Sjögren's syndrome: SS-A (Ro) and SS-B (La).
List of RNPs
This is a (partial) list of ribonucleoprotein families:
Signal recognition particle(a protein coated ribozyme)
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