Major facilitator family

Major Facilitator Superfamily
Structure of the glycerol-3-phosphate transporter from Escherichia coli.[1]
Identifiers
Symbol	MFS_1
Pfam	PF07690
InterPro	IPR011701
PROSITE	PDOC50850
SCOP	1pw4
TCDB	2.A.1
OPM family	15
OPM protein	1pw4
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

The Major Facilitator Superfamily (MFS) transporters are secondary carriers transporting small solutes in response to chemiosmotic ion gradients^[2][3].

Human proteins containing this domain

• FLVCR; FLVCR1; FLVCR2;
• HIAT1; HIATL1; HMFN2567;
• MFSD1; MFSD2; MFSD3; MFSD4; MFSD7; MFSD8; MFSD9;
• NAGLT1;
• OAT1;
• OAT1-4; OAT7; OCTN2VT;
• SLC16A1; SLC16A10; SLC16A11; SLC16A12; SLC16A13; SLC16A14; SLC16A2; SLC16A3; SLC16A4; SLC16A5; SLC16A6; SLC16A7; SLC16A8; SLC16A9; SLC17A1; SLC17A2; SLC17A3; SLC17A4; SLC17A5; SLC17A6; SLC17A7; SLC17A8; SLC18A1; SLC18A2; SLC18A3; SLC22A1; SLC22A10; SLC22A11; SLC22A12; SLC22A14; SLC22A15; SLC22A16; SLC22A17; SLC22A18; SLC22A2; SLC22A20; SLC22A3; SLC22A5; SLC22A6; SLC22A7; SLC22A8; SLC22A9; SLC2A13; SLC2A5; SLC37A1; SLC37A2; SLC37A3; SLC37A4; SLC43A2; SLC43A3; SLC45A1; SLC45A3; SLC46A1; SLC46A3;
• SPIN1; SPNS1; SPNS2; SPNS3;
• SV2A; SV2B; SV2C; SVOP; SVOPL; *TETRAN; TSCOT;
• hCT2; hOAT1; hOCT1; hROAT1;

References

1. ^ Huang Y, Lemieux MJ, Song J, Auer M, Wang DN (August 2003). "Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli". Science 301 (5633): 616–20. doi:10.1126/science.1087619. PMID 12893936. 
2. ^ Paulsen IT, Pao SS, Saier Jr MH (1998). "Major Facilitator Superfamily". Microbiol. Mol. Biol. Rev. 62 (1): 1–34. PMC 98904. PMID 9529885. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=98904. 
3. ^ Gould GW, Walmsley AR, Barrett MP, Bringaud F (1998). "Sugar transporters from bacteria, parasites and mammals: structure-activity relationships". Trends Biochem. Sci. 23 (12): 476–481. doi:10.1016/S0968-0004(98)01326-7. PMID 9868370. 

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