Nucleotide diphosphokinase

nucleotide diphosphokinase
Identifiers
EC number	2.7.6.4
CAS number	53167-92-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a nucleotide diphosphokinase (EC 2.7.6.4) is an enzyme that catalyzes the chemical reaction

ATP + nucleoside 5'-phosphate $\rightleftharpoons$ AMP + 5'-phosphonucleoside 3'-diphosphate

Thus, the two substrates of this enzyme are ATP and nucleoside 5'-phosphate, whereas its two products are AMP and 5'-phosphonucleoside 3'-diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring two phosphorus-containing groups (diphosphotransferases). The systematic name of this enzyme class is ATP:nucleoside-5'-phosphate diphosphotransferase. Other names in common use include nucleotide pyrophosphokinase, ATP:nucleotide pyrophosphotransferase, ATP nucleotide 3'-pyrophosphokinase, and nucleotide 3'-pyrophosphokinase.

References

• Murao S and Nishino T (1974). "Isolation and identification of ATP:nucleotide pyrophosphotransferase-producing microorganism". Agric. Biol. Chem. 38 (12): 2483–2489. doi:10.1271/bbb1961.38.2483. 
• Nishino T and Murao S (1974). "Purification and some properties of ATP:nucleotide pyrophosphotransferase of Streptomyces adephospholyticus". Agric. Biol. Chem. 38 (12): 2491–2496. doi:10.1271/bbb1961.38.2491. 
• Nishino T and Murao S (1975). "Characterization of pyrophosphoryl transfer reaction of ATP:nucleotide pyrophosphotransferase". Agric. Biol. Chem. 39 (5): 1007–1014. doi:10.1271/bbb1961.39.1007. 

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