N6-acetyl-beta-lysine transaminase

N6-acetyl-beta-lysine transaminase
N6-acetyl-beta-lysine transaminase
Identifiers
EC number 2.6.1.65
CAS number 71768-10-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N6-acetyl-beta-lysine transaminase (EC 2.6.1.65) is an enzyme that catalyzes the chemical reaction

6-acetamido-3-aminohexanoate + 2-oxoglutarate \rightleftharpoons 6-acetamido-3-oxohexanoate + L-glutamate

Thus, the two substrates of this enzyme are 6-acetamido-3-aminohexanoate and 2-oxoglutarate, whereas its two products are 6-acetamido-3-oxohexanoate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase. This enzyme is also called epsilon-acetyl-beta-lysine aminotransferase. This enzyme participates in lysine degradation. It employs one cofactor, pyridoxal phosphate.

References

  • Bozler G, Robertson JM, Ohsugi M, Hensley C, Barker HA (1979). "Metabolism of L-beta-lysine in a Pseudomonas: conversion of 6-N-acetyl-L-beta-lysine to 3-keto-6-acetamidohexanoate and of 4-aminobutyrate to succinic semialdehyde by different transaminases". Arch. Biochem. Biophys. 197 (1): 226–35. doi:10.1016/0003-9861(79)90240-6. PMID 44448.