D-alanine 2-hydroxymethyltransferase

D-alanine 2-hydroxymethyltransferase
D-alanine 2-hydroxymethyltransferase
Identifiers
EC number 2.1.2.7
CAS number 9075-76-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a D-alanine 2-hydroxymethyltransferase (EC 2.1.2.7) is an enzyme that catalyzes the chemical reaction

5,10-methylenetetrahydrofolate + D-alanine + H2O \rightleftharpoons tetrahydrofolate + 2-methylserine

The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, D-alanine, and H2O, whereas its two products are tetrahydrofolate and 2-methylserine.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase. This enzyme is also called 2-methylserine hydroxymethyltransferase. This enzyme participates in one carbon pool by folate.

References

  • Wilson EM and Snell EE (1962). "Metabolism of alpha-methylserine. I. alpha-Methylserine hydroxymethyltransferase". J. Biol. Chem. 237: 3171–3179. PMID 14001018. 


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