Co-tenidone Combination of Atenolol Beta blocker Chlortalidone Thiazide diuretic Clinical data Pregnancy cat. ? Legal status POM (UK) Routes Oral Identifiers ATC code ? ChemSpider (what is this?)
Co-tenidone (BAN) is a non-proprietary name used to denote a combination of atenolol and chlortalidone. Co-tenidone is used in the treatment of hypertension. The use of β-blockers in hypertension was downgraded in June 2006 in the United Kingdom to fourth-line because they perform less well than other drugs, and because atenolol, the most frequently used β-blocker, at usual doses carries an unacceptable risk of provoking type 2 diabetes.
Two strengths of co-tenidone are currently available in the UK:
- 50 mg atenolol and 12.5 mg chlortalidone , BAN of Co-tenidone 50/12.5
- 100 mg atenolol and 25 mg chlortalidone , BAN of Co-tenidone 100/25
- British National Formulary 54 September 2007
- ^ Sheetal Ladva (2006-06-28). "NICE and BHS launch updated hypertension guideline". National Institute for Health and Clinical Excellence. http://www.nelm.nhs.uk/Record%20Viewing/viewRecord.aspx?id=.
Sympatholytic (and closely related) antihypertensives (C02) Sympatholytics
vasoconstriction)CentralAdrenergic release inhibitorsImidazoline receptor agonistPeripheralIndirectTyrosine hydroxylase inhibitorDirectNon-selective α blocker
Other antagonists #WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III
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