Co-amilozide

Co-amilozide

Combination of
Amiloride	Potassium-sparing diuretic
Hydrochlorothiazide	Thiazide diuretic
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	POM (UK)
Routes	Oral
Identifiers
ATC code	C03EA01
PubChem	CID 107748
ChemSpider	96911 Y
Y(what is this?)  (verify)

Co-amilozide (BAN) is a non-proprietary name used to denote a combination of amiloride and hydrochlorothiazide. Co-amilozide is used in the treatment of hypertension and congestive heart failure with the tendency of the thiazide to cause low potassium levels (hypokalaemia) offset by the potassium-sparing effects of amiloride.

Formulation

Two strengths of co-amilozide are currently available in the UK:^[1]

• 2.5 mg amiloride and 25 mg hydrochlorothiazide, BAN of Co-amilozide 2.5/25 (brand name Moduret 25)
• 5 mg amiloride and 50 mg hydrochlorothiazide, BAN of Co-amilozide 5/50 (brand name Moduretic)

In North America:

• Moduretic (U.S., Canada)
  • Moduretic 5-50 (U.S., Canada)
• Novamilor (Canada)

Side effects

The most common side effect is headache (about 8% of people taking it) and nausea, loss of appetite, weakness, rash and dizziness (each about 3%).^[2]

Common side effects (1/10 - 1/100) include:^[2]

• General: Weakness, fatigue, loss of appetite. Headache, dizziness.
• Circulatory system: Arrhythmia.
• Gastrointestinal: Nausea, diarrhea, abdominal pain.
• Skin: Exanthema, itching.
• Respiratory system: dyspnoea, cough.
• Metabolic.: Hyperglycemia in diabetic patients, hyperuricemia.
• Musculoskeletal.: Pain in the limbs.

References

1. ^ British National Formulary 54 September 2007
2. ^ ^{a b} the Swedish official drug catalog > Normorix Retrieved on Mars 30, 2010

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.v · Categories: Potassium-sparing diuretics Thiazides Combination drugs Cardiovascular system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужна курсовая? ARESEP Mark Haydon Look at other dictionaries: co-amilozide — co amil·o·zide (ko″ə milґə zīd) pharmacy equivalent name for a combination of amiloride hydrochloride and hydrochlorothiazide; used as a diuretic in the treatment of edema, hypertension, and hypokalemia …   Medical dictionary Amiloride — Systematic (IUPAC) name 3,5 diamino 6 chloro N …   Wikipedia British Approved Name — A British Approved Name (BAN) is the official non proprietary or generic name given to a pharmaceutical substance, as defined in the British Pharmacopoeia (BP). The BAN is also the official name used in many countries across the world, especially …   Wikipedia Thiazide — is a term used to describe a type of molecule [MeshName|Thiazides] and a class of diuretic. [MeshName|Thiazide+Diuretics] The members of this class of diuretics are derived from benzothiadiazine. They inhibit Na+/Cl reabsorption from the distal… …   Wikipedia amiloride — amil·o·ride ə mil ə .rīd n a diuretic C6H8ClN7O that promotes sodium excretion and potassium retention * * * n. a potassium sparing diuretic that causes the increased excretion of sodium and chloride; it is often combined with a thiazide or loop… …   Medical dictionary amiloride — n. a potassium sparing diuretic that causes the increased excretion of sodium and chloride; it is often combined with a thiazide or loop diuretic (e.g. hydrochlorothiazide as co amilozide) to reduce the potassium loss that occurs with these drugs …   The new mediacal dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”