Morphine 6-dehydrogenase

Morphine 6-dehydrogenase
morphine 6-dehydrogenase
Identifiers
EC number 1.1.1.218
CAS number 97002-71-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a morphine 6-dehydrogenase (EC 1.1.1.218) is an enzyme that catalyzes the chemical reaction

morphine + NAD(P)+ \rightleftharpoons morphinone + NAD(P)H + H+

The 3 substrates of this enzyme are morphine, NAD+, and NADP+, whereas its 4 products are morphinone, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is morphine:NAD(P)+ 6-oxidoreductase. Other names in common use include naloxone reductase, and reductase, naloxone. This enzyme participates in alkaloid biosynthesis i. This enzyme has at least one effector, Mercaptoethanol.

References

  • Yamano S, Kageura E, Ishida T, Toki S (1985). "Purification and characterization of guinea pig liver morphine 6-dehydrogenase". J. Biol. Chem. 260 (9): 5259–64. PMID 2580834. 
  • Yamano S, Nishida F, Toki S (1986). "Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase". Biochem. Pharmacol. 35 (23): 4321–6. doi:10.1016/0006-2952(86)90712-4. PMID 3539118. 
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