Orotidine

Orotidine
Orotidine
Identifiers
CAS number 314-50-1
PubChem 92751
ChemSpider 83729 YesY
Jmol-3D images Image 1
Properties
Molecular formula C10H12N2O8
Molar mass 288.213 g/mol
Density x.xxx g/cm3
Melting point

200°C

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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Orotidine is a nucleoside formed by attaching orotic acid to a ribose ring via a β-N1-glycosidic bond. It is found in bacteria, fungi and plants. It was first isolated in 1951 from the fungus Neurospora by A. Michael Michelson, William Drell, and Herschel K. Mitchell.[1] In humans, orotidine occurs as its 5'-phosphate (orotidylic acid), which is an intermediate in pyrimidine nucleotide biosynthesis (cytidine and uridine) that are found in nucleic acids. Orotidine itself is not a component of nucleic acid. Large amounts of orotidine are excreted in the urine of cancer patients treated with 6-azauridine.

The symbol commonly used for orotidine is O or Ord.

Note

  1. ^ A. Michael Michelson, William Drell, Herschel K. Mitchell (1951). "A new ribose nucleoside from Neurospora: "orotidine"". Proc Natl Acad Sci USA 37 (7): 396–399. doi:10.1073/pnas.37.7.396. PMC 1063384. PMID 14853953. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1063384.  Full text at PMC: 1063384 Free full text at PNAS

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Look at other dictionaries:

  • orotidine — Orotic acid 3 β d ribonucleoside; uridine 6 carboxylic acid; elevated in cases of orotidinuria. SYN: 1 ribosylorotate. o. 5′ monophosphate (OMP) SYN: orotidylic acid. * * * orot·i·dine (ə rotґĭ dēn) a nucleoside, orotic acid linked …   Medical dictionary

  • orotidine-5 — phosphate decarboxylase (ODC) orot·i·dine 5‵ phos·phate de·car·box·y·lase (ODC) (ə rotґĭ dēn fosґfāt de″kahr bokґsə lās) [EC 4.1.1.23] an enzyme of the lyase class that catalyzes the decarboxylation of… …   Medical dictionary

  • orotidine — orotidinas statusas T sritis chemija apibrėžtis Nukleozidas. santrumpa( os) Ord atitikmenys: angl. orotidine rus. оротидин ryšiai: sinonimas – 3 β D ribofuranoziloroto rūgštis …   Chemijos terminų aiškinamasis žodynas

  • Orotidine 5'-phosphate decarboxylase — E. coli OMP decarboxylase.[1] Identifiers EC number …   Wikipedia

  • Orotidine 5'-monophosphate — IUPAC name 3 [(2R,3R,4S,5R) 3,4 dihydroxy 5 ​(phosphonooxymethyl)oxolan 2 yl]​ 2,6 dioxo pyrimid …   Wikipedia

  • orotidine-5’-phosphate decarboxylase — orotidine 5’ phosphate decarboxylase. = orotate phosphoribosyl transferase (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • orotidine-5ˊ-monophosphate — orotidin 5ˊ monofosfatas statusas T sritis chemija apibrėžtis Nukleotidas. santrumpa( os) OMP atitikmenys: angl. orotidine 5ˊ monophosphate rus. оротидин 5ˊ монофосфат …   Chemijos terminų aiškinamasis žodynas

  • orotidine — noun A nucleoside formed by reaction of orotic acid with ribose …   Wiktionary

  • orotate phosphoribosyl transferase/orotidine-5’-phosphate decarboxylase — orotate phosphoribosyl transferase/orotidine 5’ phosphate decarboxylase. См. оротат фосфорибозилтрансфераза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • orotidylic acid — Orotidine 5′ monophosphate; an intermediate in the biosynthesis of the pyrimidine nucleosides (cytidine and uridine) that are found in nucleic acid s. SYN: orotidine 5′ monophosphate. o. decarboxylase an enzyme that catalyzes the conversion of… …   Medical dictionary

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