cAMP receptor protein

cAMP receptor protein
CAMP receptor protein
1i5z.jpg
Structure of the E. coli Cyclic AMP Receptor Protein.
Identifiers
Symbol CRP
Alt. symbols CAP
Entrez 947867
PDB 1I5Z
RefSeq NP_417816.1
UniProt P0ACJ8
Other data

cAMP receptor protein (in short CRP, also known as catabolite gene activator protein (in short CAP)) is a regulatory protein in bacteria. This protein binds cAMP, which causes a conformational change that allows the protein to bind tightly to a specific DNA sequence in the promoters of the genes it controls.[1] The genes regulated by this protein are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system.[2][3]

References

  1. ^ Harman JG (2001). "Allosteric regulation of the cAMP receptor protein". Biochim. Biophys. Acta 1547 (1): 1–17. doi:10.1016/S0167-4838(01)00187-X. PMID 11343786. 
  2. ^ Weickert MJ, Adhya S (1993). "The galactose regulon of Escherichia coli". Mol. Microbiol. 10 (2): 245–51. doi:10.1111/j.1365-2958.1993.tb01950.x. PMID 7934815. 
  3. ^ Bott M (1997). "Anaerobic citrate metabolism and its regulation in enterobacteria". Arch. Microbiol. 167 (2–3): 78–88. doi:10.1007/s002030050419. PMID 9133329. 

External links