- 7,12-Dimethylbenz(a)anthracene
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7,12-Dimethylbenz(a)anthracene[1] 7,12-dimethylbenzo[b]phenanthreneIdentifiers CAS number 57-97-6 PubChem 6001 ChemSpider 5779 ChEBI CHEBI:254496 ChEMBL CHEMBL329673 Jmol-3D images Image 1 - c32c(c1ccccc1c(c2ccc4c3cccc4)C)C
Properties Molecular formula C20H16 Molar mass 256.34104 Melting point 122-123 °C
Hazards R-phrases R45 R22 S-phrases S53 S36/37 S45 Main hazards T (Toxic) (verify) (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)Infobox references 7,12-Dimethylbenz(a)anthracene is an immunosuppressor and a powerful organ-specific laboratory carcinogen.[2] Also known as 7,12-dimethylbenz[α]anthracene or DMBA, this substance is widely used in many research laboratories studying cancer. DMBA serves as a tumor initiator by making necessary mutations. Tumor promotion can be induced with treatments of TPA (12-O-tetradecanoylphorbol-13-acetate) in some models of two-stage carcinogenesis.[3] This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible.
References
- ^ 7,12-Dimethylbenz(a)anthracene at Sigma-Aldrich
- ^ Miyata M, Furukawa M, Takahashi K, Gonzalez FJ, Yamazoe Y. (2001) Mechanism of 7, 12-Dimethylbenz[a]anthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ. Jpn J Pharmacol 86:302-309. Link
- ^ Sung YM, He G, Fischer, SM. (2005) Lack of Expression of the EP2 but not EP3 Receptor for Prostaglandin E2 Results in Suppression of Skin Tumor Development. Cancer Res 65:9304-9311
Categories:- Polycyclic aromatic hydrocarbons
- Carcinogens
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