12-O-Tetradecanoylphorbol-13-acetate
- 12-O-Tetradecanoylphorbol-13-acetate
Chembox new
Name = Tetradecanoylphorbol acetate
ImageFile = Tetradecanoylphorbol_acetate.png ImageName = TPA
IUPACName =12-O-tetradecanoylphorbol-13-acetate
OtherNames = TPA, PMA, Phorbol myristate acetate,
Tetradecanoylphorbol acetate.
Section1 = Chembox Identifiers
CASNo = 16561-29-8
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PubChem
PubChem|10475874
Section2 = Chembox Properties
Formula = C36H56O8
MolarMass = 616.83 g/mol
12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as phorbol 12-myristate 13-acetate (PMA), is diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol.TPA is also being studied as a drug in the treatment of hematologic cancer. TPA is not to be confused with tPA; the former is a small molecule drug, whereas the latter is an enzyme.TPA was first found in the croton plant, a shrub found in Southeast Asia, exposure to which provokes a poison ivy-like rash. It is currently undergoing phase 1 clinical trials.
References
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Look at other dictionaries:
12-O-tetradecanoylphorbol 13-acetate — A double ester of phorbol found in croton oil; a cocarcinogen or tumor promoter … Medical dictionary
12-O-tetradecanoylphorbol-13-acetate — TPA. A substance being studied in the treatment of hematologic cancers. It is a type of phorbol ester. Also called TPA … English dictionary of cancer terms
PMA — puede referirse a: Post mortem auctoris, término latino Programa Mundial de Alimentos Países menos avanzados Philadelphia Museum of Art Términos médicos Atrofia muscular progresiva (Progressive muscular atrophy) Área pre motora del córtex motor… … Wikipedia Español
TPA — may refer to:* Tampa International Airport (IATA code) * Tempe Preparatory Academy, a preparatory secondary school in Arizona, USA * Third party administrator, a financial transaction administrator that handles the processing and paperwork for… … Wikipedia
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TPA — 12 O tetradecanoylphorbol 13 acetate. A substance being studied in the treatment of hematologic cancers. It is a type of phorbol ester. Also called 12 O tetradecanoylphorbol 13 acetate … English dictionary of cancer terms
List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * … Wikipedia
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Midkine — For other uses, see Mk (disambiguation) and MDK (disambiguation). Midkine (neurite growth promoting factor 2) PDB rendering based on 1mkc … Wikipedia
