OVGP1

Oviductal glycoprotein 1, 120kDa
Identifiers
Symbols	OVGP1; CHIT5; EGP; MUC9; OGP
External IDs	OMIM: 603578 MGI: 106661 HomoloGene: 74442 GeneCards: OVGP1 Gene
Gene Ontology Molecular function • catalytic activity • chitinase activity • cation binding Cellular component • transport vesicle • cytoplasmic vesicle Biological process • carbohydrate metabolic process • chitin catabolic process • single fertilization • female pregnancy Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5016	12659
Ensembl	ENSG00000085465	ENSMUSG00000074340
UniProt	Q12889	Q54AJ4
RefSeq (mRNA)	NM_002557	NM_007696.2
RefSeq (protein)	NP_002548	NP_031722.1
Location (UCSC)	Chr 1: 111.96 – 111.97 Mb	Chr 3: 105.78 – 105.79 Mb
PubMed search	[1]	[2]

Oviduct-specific glycoprotein also known as oviductal glycoprotein (OGP) or estrogen-dependent oviduct protein (EGP) or mucin-9 (MUC9) is a protein that in humans is encoded by the OVGP1 gene.^[1][2][3]

Function

Oviduct-specific glycoprotein is a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions.^[3]

References

1. ^ Arias EB, Verhage HG, Jaffe RC (Feb 1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biol Reprod 51 (4): 685–94. doi:10.1095/biolreprod51.4.685. PMID 7819450. 
2. ^ Lapensee L, Paquette Y, Bleau G (Nov 1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertil Steril 68 (4): 702–8. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614. 
3. ^ ^{a b} "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5016. 

Further reading

• Verhage HG, Fazleabas AT, Donnelly K (1988). "The in vitro synthesis and release of proteins by the human oviduct". Endocrinology 122 (4): 1639–45. doi:10.1210/endo-122-4-1639. PMID 3278893. 
• Iontcheva I, Oppenheim FG, Troxler RF (1997). "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins". J. Dent. Res. 76 (3): 734–43. doi:10.1177/00220345970760030501. PMID 9109822. 
• Iontcheva I, Oppenheim FG, Offner GD, Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system". J. Dent. Res. 79 (2): 732–9. doi:10.1177/00220345000790020601. PMID 10728974. 
• Agarwal A, Yeung WS, Lee KF (2002). "Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter". Mol. Hum. Reprod. 8 (2): 167–75. doi:10.1093/molehr/8.2.167. PMID 11818519. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Lok IH, Briton-Jones CM, Yuen PM, Haines CJ (2003). "Variable expression of oviductin mRNA at different stages of human reproductive cycle". J. Assist. Reprod. Genet. 19 (12): 569–76. doi:10.1023/A:1021263132176. PMID 12503889. 
• Chen Q, Zhang J, Sweet F (2004). "Homology of primate DNA fragments for estrous-associated oviductal glycoprotein". Hereditas 139 (1): 75–9. doi:10.1111/j.1601-5223.2003.01640.x. PMID 14641477. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Woo MM, Alkushi A, Verhage HG et al. (2005). "Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer". Clin. Cancer Res. 10 (23): 7958–64. doi:10.1158/1078-0432.CCR-04-1261. PMID 15585630. 
• Ling L, Lee YL, Lee KF et al. (2006). "Expression of human oviductin in an immortalized human oviductal cell line". Fertil. Steril. 84 Suppl 2: 1095–103. doi:10.1016/j.fertnstert.2005.06.006. PMID 16209999. 
• Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U (2006). "Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9". Mol. Hum. Reprod. 12 (4): 275–82. doi:10.1093/molehr/gal028. PMID 16567366. 
• Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.