Compartment (pharmacokinetics)
- Compartment (pharmacokinetics)
-
In pharmacokinetics, a compartment is a defined volume of body fluids. It is distinguished from anatomic compartments, which are bounded by fasciae. It is used in multi-compartment models.
Examples
There are five major body compartments[1]:
The transcellular compartment includes fluids in the pleural cavity or peritoneal cavity.
Comparison table
| Compartment |
estimated % of body mass[2] |
| blood plasma |
5 |
| interstitial fluid |
16 |
| fat tissue |
20 (see also body fat percentage) |
| intracellular fluid |
35 |
| transcellular fluid |
2 |
Mnemonic: 60-40-20-15-5: % of TBW, Intracellular fluid, Extracellular fluid, interstitial fluid, plasma
References
- ^ Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 102
- ^ Unless else specified in table, then ref s: Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 102
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