Pharmacogenomics

Pharmacogenomics is the branch of pharmacology which deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. By doing so, pharmacogenomics aims to develop rational means to optimise drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Such approaches promise the advent of "personalized medicine", in which drugs and drug combinations are optimised for each individual's unique genetic makeup. [cite web|url=http://www.fda.gov/cder/guidance/6400fnl.pdf|title=Guidance for Industry Pharmacogenomic Data Submissions|date=March 2005|publisher=U.S. Food and Drug Administration|accessdate=2008-08-27]

Pharmacogenomics is the whole genome application of pharmacogenetics, which examines the single gene interactions with drugs.

References

ee also

* Genomics
** Chemogenomics
** Structural genomics
** Pharmacogenetics
** Toxicogenomics
** Clinomics
*Pharmaceutical company

External links

* [http://www.fda.gov/cder/genomics Genomics @ FDA] FDA's resource on genomics
* [http://astore.amazon.com/pharmacologyd-20/detail/1588298876/102-8665168-3357719 Pharmacogenomics in Drug Discovery and Development] , a book on pharmacogenomics, diseases, and therapeutics
* [http://www.nature.com/omics/subjects/pharmacogenomics/index.html Nature pharmacogenomics gateway]
* [http://www.pharmgkb.org PharmGKB] The Pharmacogenetics and Pharmacogenomics Knowledge Base, an online free tool for Pharmacogenomics research
* [http://www.ncbi.nlm.nih.gov/About/primer/pharm.html NCBI Primer on Pharmacogenomics] , a quick introduction to the promise of customised drugs.
* [http://gslc.genetics.utah.edu/units/pharma/ Pharmacogenomics: Drugs Designed for You] , an accessible and comprehensive look at pharmacogenomics research, from the University of Utah's Genetic Science Learning Center
* [http://www.sciam.com/article.cfm?chanID=sa004&articleID=0006C064-7701-12ED-B70183414B7F0000 A Drug to Call One's Own : Will medicine finally get personal?] - Scientific American Magazine (August 2005)