DBF4

DBF4 homolog (S. cerevisiae)
Identifiers
Symbols	DBF4; ASK; CHIF; DBF4A; ZDBF1
External IDs	OMIM: 604281 MGI: 1351328 HomoloGene: 40892 GeneCards: DBF4 Gene
Gene Ontology Molecular function • nucleic acid binding • protein binding • enzyme activator activity • zinc ion binding • metal ion binding Cellular component • intracellular • nucleus • nucleoplasm • nucleoplasm Biological process • cell cycle checkpoint • G1/S transition of mitotic cell cycle • M/G1 transition of mitotic cell cycle • mitotic cell cycle • DNA replication • positive regulation of catalytic activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10926	27214
Ensembl	ENSG00000006634	ENSMUSG00000002297
UniProt	Q9UBU7	Q80YS2
RefSeq (mRNA)	NM_006716	NM_013726
RefSeq (protein)	NP_006707	NP_038754
Location (UCSC)	Chr 7: 87.51 – 87.54 Mb	Chr 5: 8.4 – 8.42 Mb
PubMed search	[1]	[2]

Protein DBF4 homolog A is a protein that in humans is encoded by the DBF4 gene.^[1][2][3]

Interactions

DBF4 has been shown to interact with ORC2L,^[4] MCM7,^[4] Cell division cycle 7-related protein kinase,^[1][4][5] MCM3^[4] and ORC6L.^[4]

References

1. ^ ^{a b} Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H (Jul 1999). "A Novel Growth- and Cell Cycle-Regulated Protein, ASK, Activates Human Cdc7-Related Kinase and Is Essential for G1/S Transition in Mammalian Cells". Mol Cell Biol 19 (7): 5083–95. PMC 84351. PMID 10373557. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84351. 
2. ^ Lepke M, Putter V, Staib C, Kneissl M, Berger C, Hoehn K, Nanda I, Schmid M, Grummt F (Nov 1999). "Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes". Mol Gen Genet 262 (2): 220–9. doi:10.1007/s004380051078. PMID 10517317. 
3. ^ "Entrez Gene: DBF4 DBF4 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10926. 
4. ^ ^{a b c d e} Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
5. ^ Jiang, W; McDonald D, Hope T J, Hunter T (Oct. 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". EMBO J. (ENGLAND) 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. ISSN 0261-4189. PMC 1171637. PMID 10523313. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171637. 

Further reading

• Jiang W, McDonald D, Hope TJ, Hunter T (1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". EMBO J. 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMC 1171637. PMID 10523313. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171637. 
• Yamada M, Sato N, Taniyama C, et al. (2002). "A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase". J. Biol. Chem. 277 (31): 27668–81. doi:10.1074/jbc.M202884200. PMID 12015319. 
• Wu X, Lee H (2002). "Human Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elements". Oncogene 21 (51): 7786–96. doi:10.1038/sj.onc.1205914. PMID 12420215. 
• Duncker BP, Shimada K, Tsai-Pflugfelder M, et al. (2003). "An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16087–92. doi:10.1073/pnas.252093999. PMC 138569. PMID 12441400. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=138569. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Costanzo V, Shechter D, Lupardus PJ, et al. (2003). "An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication". Mol. Cell 11 (1): 203–13. doi:10.1016/S1097-2765(02)00799-2. PMID 12535533. 
• Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Schnepp RW, Hou Z, Wang H, et al. (2004). "Functional interaction between tumor suppressor menin and activator of S-phase kinase". Cancer Res. 64 (18): 6791–6. doi:10.1158/0008-5472.CAN-04-0724. PMID 15374998. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Gérard A, Koundrioukoff S, Ramillon V, et al. (2006). "The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen". EMBO Rep. 7 (8): 817–23. doi:10.1038/sj.embor.7400750. PMC 1525143. PMID 16826239. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1525143. 
• Tsuji T, Ficarro SB, Jiang W (2007). "Essential Role of Phosphorylation of MCM2 by Cdc7/Dbf4 in the Initiation of DNA Replication in Mammalian Cells". Mol. Biol. Cell 17 (10): 4459–72. doi:10.1091/mbc.E06-03-0241. PMC 1635350. PMID 16899510. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1635350. 
• Heffernan TP, Unsal-Kaçmaz K, Heinloth AN, et al. (2007). "Cdc7/Dbf4 and the Human S Checkpoint Response to UVC". J. Biol. Chem. 282 (13): 9458–68. doi:10.1074/jbc.M611292200. PMC 1839878. PMID 17276990. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1839878. 

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР The Dead Man's Knock SEC61B Look at other dictionaries: Cell division cycle 7-related protein kinase — Cell division cycle 7 homolog (S. cerevisiae), also known as CDC7, is a human gene.cite web | title = Entrez Gene: CDC7 cell division cycle 7 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia Control of chromosome duplication — A key feature of the DNA replication mechanism in eukaryotes is that it is designed to replicate relatively large genomes rapidly and with high fidelity. Replication is initiated at multiple origins of replication on multiple chromosomes… …   Wikipedia ORC2L — Origin recognition complex, subunit 2 Identifiers Symbols ORC2; ORC2 External IDs OM …   Wikipedia ORC6L — Origin recognition complex, subunit 6 Identifiers Symbols ORC6; ORC6 External IDs O …   Wikipedia DDK — is a three letter abbreviation which can mean several things: In software development, a driver development kit, Used on the hull of a ship United States Navy ship, it indicates a Hunter Killer Destroyer. Dysdiadochokinesia, a symptom of… …   Wikipedia MCM2 — minichromosome maintenance deficient 2, mitotin (S. cerevisiae), also known as MCM2, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is one of the highly conserved mini chromosome maintenance proteins… …   Wikipedia ORC1L — Origin recognition complex, subunit 1 like (yeast), also known as ORC1L, is a human gene.cite web | title = Entrez Gene: ORC1L origin recognition complex, subunit 1 like (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia ORC4L — Origin recognition complex, subunit 4 Identifiers Symbols ORC4; FLJ46668; ORC4L; ORC4P External IDs …   Wikipedia ORC5L — Origin recognition complex, subunit 5 Identifiers Symbols ORC5; ORC5L; ORC5P; ORC5T External IDs …   Wikipedia Menin — Masse/Länge Primärstruktur 615 Aminosäuren …   Deutsch Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”