DBF4

DBF4 homolog (S. cerevisiae)
Identifiers
Symbols	DBF4; ASK; CHIF; DBF4A; ZDBF1
External IDs	OMIM: 604281 MGI: 1351328 HomoloGene: 40892 GeneCards: DBF4 Gene
Gene Ontology Molecular function • nucleic acid binding • protein binding • enzyme activator activity • zinc ion binding • metal ion binding Cellular component • intracellular • nucleus • nucleoplasm • nucleoplasm Biological process • cell cycle checkpoint • G1/S transition of mitotic cell cycle • M/G1 transition of mitotic cell cycle • mitotic cell cycle • DNA replication • positive regulation of catalytic activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10926	27214
Ensembl	ENSG00000006634	ENSMUSG00000002297
UniProt	Q9UBU7	Q80YS2
RefSeq (mRNA)	NM_006716	NM_013726
RefSeq (protein)	NP_006707	NP_038754
Location (UCSC)	Chr 7: 87.51 – 87.54 Mb	Chr 5: 8.4 – 8.42 Mb
PubMed search	[1]	[2]

Protein DBF4 homolog A is a protein that in humans is encoded by the DBF4 gene.^[1][2][3]

Interactions

DBF4 has been shown to interact with ORC2L,^[4] MCM7,^[4] Cell division cycle 7-related protein kinase,^[1][4][5] MCM3^[4] and ORC6L.^[4]

References

1. ^ ^{a b} Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H (Jul 1999). "A Novel Growth- and Cell Cycle-Regulated Protein, ASK, Activates Human Cdc7-Related Kinase and Is Essential for G1/S Transition in Mammalian Cells". Mol Cell Biol 19 (7): 5083–95. PMC 84351. PMID 10373557. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84351. 
2. ^ Lepke M, Putter V, Staib C, Kneissl M, Berger C, Hoehn K, Nanda I, Schmid M, Grummt F (Nov 1999). "Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes". Mol Gen Genet 262 (2): 220–9. doi:10.1007/s004380051078. PMID 10517317. 
3. ^ "Entrez Gene: DBF4 DBF4 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10926. 
4. ^ ^{a b c d e} Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
5. ^ Jiang, W; McDonald D, Hope T J, Hunter T (Oct. 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". EMBO J. (ENGLAND) 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. ISSN 0261-4189. PMC 1171637. PMID 10523313. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171637. 

Further reading

• Jiang W, McDonald D, Hope TJ, Hunter T (1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". EMBO J. 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMC 1171637. PMID 10523313. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171637. 
• Yamada M, Sato N, Taniyama C, et al. (2002). "A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase". J. Biol. Chem. 277 (31): 27668–81. doi:10.1074/jbc.M202884200. PMID 12015319. 
• Wu X, Lee H (2002). "Human Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elements". Oncogene 21 (51): 7786–96. doi:10.1038/sj.onc.1205914. PMID 12420215. 
• Duncker BP, Shimada K, Tsai-Pflugfelder M, et al. (2003). "An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16087–92. doi:10.1073/pnas.252093999. PMC 138569. PMID 12441400. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=138569. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Costanzo V, Shechter D, Lupardus PJ, et al. (2003). "An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication". Mol. Cell 11 (1): 203–13. doi:10.1016/S1097-2765(02)00799-2. PMID 12535533. 
• Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Schnepp RW, Hou Z, Wang H, et al. (2004). "Functional interaction between tumor suppressor menin and activator of S-phase kinase". Cancer Res. 64 (18): 6791–6. doi:10.1158/0008-5472.CAN-04-0724. PMID 15374998. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Gérard A, Koundrioukoff S, Ramillon V, et al. (2006). "The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen". EMBO Rep. 7 (8): 817–23. doi:10.1038/sj.embor.7400750. PMC 1525143. PMID 16826239. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1525143. 
• Tsuji T, Ficarro SB, Jiang W (2007). "Essential Role of Phosphorylation of MCM2 by Cdc7/Dbf4 in the Initiation of DNA Replication in Mammalian Cells". Mol. Biol. Cell 17 (10): 4459–72. doi:10.1091/mbc.E06-03-0241. PMC 1635350. PMID 16899510. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1635350. 
• Heffernan TP, Unsal-Kaçmaz K, Heinloth AN, et al. (2007). "Cdc7/Dbf4 and the Human S Checkpoint Response to UVC". J. Biol. Chem. 282 (13): 9458–68. doi:10.1074/jbc.M611292200. PMC 1839878. PMID 17276990. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1839878. 

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