MCM7

MCM7 minichromosome maintenance deficient 7 (S. cerevisiae), also known as MCM7, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4176| accessdate = ]

ee also

*Mini Chromosome Maintenance

References

PBB_Further_reading
citations =
*cite journal | author=Todorov IT, Lavigne J, Sakr F, "et al." |title=Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle. |journal=Biochem. Biophys. Res. Commun. |volume=177 |issue= 1 |pages= 395–400 |year= 1991 |pmid= 1710453 |doi=
*cite journal | author=Musahl C, Schulte D, Burkhart R, Knippers R |title=A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins. |journal=Eur. J. Biochem. |volume=230 |issue= 3 |pages= 1096–101 |year= 1995 |pmid= 7601140 |doi=
*cite journal | author=Nakatsuru S, Sudo K, Nakamura Y |title=Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 3-4 |pages= 226–30 |year= 1995 |pmid= 7842741 |doi=
*cite journal | author=Mincheva A, Todorov I, Werner D, "et al." |title=The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21. |journal=Cytogenet. Cell Genet. |volume=65 |issue= 4 |pages= 276–7 |year= 1994 |pmid= 8258304 |doi=
*cite journal | author=Hu B, Burkhart R, Schulte D, "et al." |title=The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. |journal=Nucleic Acids Res. |volume=21 |issue= 23 |pages= 5289–93 |year= 1994 |pmid= 8265339 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Fujita M, Kiyono T, Hayashi Y, Ishibashi M |title=hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4349–54 |year= 1996 |pmid= 8626784 |doi=
*cite journal | author=Schulte D, Richter A, Burkhart R, "et al." |title=Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins. |journal=Eur. J. Biochem. |volume=235 |issue= 1-2 |pages= 144–51 |year= 1996 |pmid= 8631321 |doi=
*cite journal | author=Kiyono T, Fujita M, Hayashi Y, Ishibashi M |title=Cloning of a cDNA encoding a human homologue of CDC47, a member of the MCM family. |journal=Biochim. Biophys. Acta |volume=1307 |issue= 1 |pages= 31–4 |year= 1996 |pmid= 8652665 |doi=
*cite journal | author=Ishimi Y, Ichinose S, Omori A, "et al." |title=Binding of human minichromosome maintenance proteins with histone H3. |journal=J. Biol. Chem. |volume=271 |issue= 39 |pages= 24115–22 |year= 1996 |pmid= 8798650 |doi=
*cite journal | author=Fujita M, Kiyono T, Hayashi Y, Ishibashi M |title=In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP. |journal=J. Biol. Chem. |volume=272 |issue= 16 |pages= 10928–35 |year= 1997 |pmid= 9099751 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Hiraiwa A, Fujita M, Nagasaka T, "et al." |title=Immunolocalization of hCDC47 protein in normal and neoplastic human tissues and its relation to growth. |journal=Int. J. Cancer |volume=74 |issue= 2 |pages= 180–4 |year= 1997 |pmid= 9133452 |doi=
*cite journal | author=Ishimi Y |title=A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24508–13 |year= 1997 |pmid= 9305914 |doi=
*cite journal | author=Sterner JM, Dew-Knight S, Musahl C, "et al." |title=Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2748–57 |year= 1998 |pmid= 9566894 |doi=
*cite journal | author=Suzuki S, Adachi A, Hiraiwa A, "et al." |title=Cloning and characterization of human MCM7 promoter. |journal=Gene |volume=216 |issue= 1 |pages= 85–91 |year= 1998 |pmid= 9714754 |doi=
*cite journal | author=Kühne C, Banks L |title=E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34302–9 |year= 1999 |pmid= 9852095 |doi=
*cite journal | author=Fujita M, Yamada C, Goto H, "et al." |title=Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation. |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25927–32 |year= 1999 |pmid= 10464337 |doi=
*cite journal | author=Freeman A, Morris LS, Mills AD, "et al." |title=Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. |journal=Clin. Cancer Res. |volume=5 |issue= 8 |pages= 2121–32 |year= 1999 |pmid= 10473096 |doi=
*cite journal | author=Kukimoto I, Igaki H, Kanda T |title=Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha. |journal=Eur. J. Biochem. |volume=265 |issue= 3 |pages= 936–43 |year= 1999 |pmid= 10518787 |doi=

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