MCM4

MCM4 minichromosome maintenance deficient 4 (S. cerevisiae), also known as MCM4, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.cite web | title = Entrez Gene: MCM4 MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4173| accessdate = ]

ee also

*Mini Chromosome Maintenance

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Musahl C, Schulte D, Burkhart R, Knippers R |title=A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins. |journal=Eur. J. Biochem. |volume=230 |issue= 3 |pages= 1096–101 |year= 1995 |pmid= 7601140 |doi=
*cite journal | author=Hu B, Burkhart R, Schulte D, "et al." |title=The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. |journal=Nucleic Acids Res. |volume=21 |issue= 23 |pages= 5289–93 |year= 1994 |pmid= 8265339 |doi=
*cite journal | author=Schulte D, Richter A, Burkhart R, "et al." |title=Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins. |journal=Eur. J. Biochem. |volume=235 |issue= 1-2 |pages= 144–51 |year= 1996 |pmid= 8631321 |doi=
*cite journal | author=Ishimi Y, Ichinose S, Omori A, "et al." |title=Binding of human minichromosome maintenance proteins with histone H3. |journal=J. Biol. Chem. |volume=271 |issue= 39 |pages= 24115–22 |year= 1996 |pmid= 8798650 |doi=
*cite journal | author=Ladenburger EM, Fackelmayer FO, Hameister H, Knippers R |title=MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-->q13. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 268–70 |year= 1997 |pmid= 9284934 |doi=
*cite journal | author=Ishimi Y |title=A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24508–13 |year= 1997 |pmid= 9305914 |doi=
*cite journal | author=Connelly MA, Zhang H, Kieleczawa J, Anderson CW |title=The promoters for human DNA-PKcs (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11. |journal=Genomics |volume=47 |issue= 1 |pages= 71–83 |year= 1998 |pmid= 9465298 |doi= 10.1006/geno.1997.5076
*cite journal | author=Fujita M, Yamada C, Tsurumi T, "et al." |title=Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 17095–101 |year= 1998 |pmid= 9642275 |doi=
*cite journal | author=You Z, Komamura Y, Ishimi Y |title=Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity. |journal=Mol. Cell. Biol. |volume=19 |issue= 12 |pages= 8003–15 |year= 2000 |pmid= 10567526 |doi=
*cite journal | author=Ishimi Y, Komamura-Kohno Y, You Z, "et al." |title=Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 16235–41 |year= 2000 |pmid= 10748114 |doi= 10.1074/jbc.M909040199
*cite journal | author=Izumi M, Yanagi K, Mizuno T, "et al." |title=The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. |journal=Nucleic Acids Res. |volume=28 |issue= 23 |pages= 4769–77 |year= 2001 |pmid= 11095689 |doi=
*cite journal | author=Lee JK, Hurwitz J |title=Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 1 |pages= 54–9 |year= 2001 |pmid= 11136247 |doi= 10.1073/pnas.98.1.54
*cite journal | author=Ishimi Y, Komamura-Kohno Y |title=Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6,7 helicase activity. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34428–33 |year= 2001 |pmid= 11454864 |doi= 10.1074/jbc.M104480200
*cite journal | author=You Z, Ishimi Y, Masai H, Hanaoka F |title=Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42471–9 |year= 2003 |pmid= 12207017 |doi= 10.1074/jbc.M205769200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kneissl M, Pütter V, Szalay AA, Grummt F |title=Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. |journal=J. Mol. Biol. |volume=327 |issue= 1 |pages= 111–28 |year= 2003 |pmid= 12614612 |doi=
*cite journal | author=Yabuta N, Kajimura N, Mayanagi K, "et al." |title=Mammalian Mcm2/4/6/7 complex forms a toroidal structure. |journal=Genes Cells |volume=8 |issue= 5 |pages= 413–21 |year= 2004 |pmid= 12694531 |doi=
*cite journal | author=Ishimi Y, Komamura-Kohno Y, Kwon HJ, "et al." |title=Identification of MCM4 as a target of the DNA replication block checkpoint system. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24644–50 |year= 2003 |pmid= 12714602 |doi= 10.1074/jbc.M213252200
*cite journal | author=Johnson EM, Kinoshita Y, Daniel DC |title=A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13. |journal=Nucleic Acids Res. |volume=31 |issue= 11 |pages= 2915–25 |year= 2003 |pmid= 12771218 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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