ORC1L

Origin recognition complex, subunit 1-like (yeast), also known as ORC1L, is a human gene.cite web | title = Entrez Gene: ORC1L origin recognition complex, subunit 1-like (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4998| accessdate = ]

PBB_Summary
section_title =
summary_text = The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.cite web | title = Entrez Gene: ORC1L origin recognition complex, subunit 1-like (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4998| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gavin KA, Hidaka M, Stillman B |title=Conserved initiator proteins in eukaryotes. |journal=Science |volume=270 |issue= 5242 |pages= 1667–71 |year= 1996 |pmid= 7502077 |doi=
*cite journal | author=Eki T, Okumura K, Amin A, "et al." |title=Mapping of the human homologue (ORC1L) of the yeast origin recognition complex subunit 1 gene to chromosome band 1p32. |journal=Genomics |volume=36 |issue= 3 |pages= 559–61 |year= 1997 |pmid= 8884289 |doi= 10.1006/geno.1996.0511
*cite journal | author=Ohtani K, DeGregori J, Leone G, "et al." |title=Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 6977–84 |year= 1997 |pmid= 8943353 |doi=
*cite journal | author=Saha P, Chen J, Thome KC, "et al." |title=Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2758–67 |year= 1998 |pmid= 9566895 |doi=
*cite journal | author=Iizuka M, Stillman B |title=Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23027–34 |year= 1999 |pmid= 10438470 |doi=
*cite journal | author=Jiang W, McDonald D, Hope TJ, Hunter T |title=Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5703–13 |year= 1999 |pmid= 10523313 |doi= 10.1093/emboj/18.20.5703
*cite journal | author=Tatsumi Y, Tsurimoto T, Shirahige K, "et al." |title=Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5904–10 |year= 2000 |pmid= 10681582 |doi=
*cite journal | author=Thome KC, Dhar SK, Quintana DG, "et al." |title=Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 35233–41 |year= 2001 |pmid= 10954718 |doi= 10.1074/jbc.M005765200
*cite journal | author=Vashee S, Simancek P, Challberg MD, Kelly TJ |title=Assembly of the human origin recognition complex. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26666–73 |year= 2001 |pmid= 11323433 |doi= 10.1074/jbc.M102493200
*cite journal | author=Laman H, Peters G, Jones N |title=Cyclin-mediated export of human Orc1. |journal=Exp. Cell Res. |volume=271 |issue= 2 |pages= 230–7 |year= 2002 |pmid= 11716535 |doi= 10.1006/excr.2001.5360
*cite journal | author=Fujita M, Ishimi Y, Nakamura H, "et al." |title=Nuclear organization of DNA replication initiation proteins in mammalian cells. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10354–61 |year= 2002 |pmid= 11779870 |doi= 10.1074/jbc.M111398200
*cite journal | author=Ladenburger EM, Keller C, Knippers R |title=Identification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replication. |journal=Mol. Cell. Biol. |volume=22 |issue= 4 |pages= 1036–48 |year= 2002 |pmid= 11809796 |doi=
*cite journal | author=Méndez J, Zou-Yang XH, Kim SY, "et al." |title=Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. |journal=Mol. Cell |volume=9 |issue= 3 |pages= 481–91 |year= 2002 |pmid= 11931757 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kneissl M, Pütter V, Szalay AA, Grummt F |title=Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. |journal=J. Mol. Biol. |volume=327 |issue= 1 |pages= 111–28 |year= 2003 |pmid= 12614612 |doi=
*cite journal | author=Ohta S, Tatsumi Y, Fujita M, "et al." |title=The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle. |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 41535–40 |year= 2003 |pmid= 12909626 |doi= 10.1074/jbc.M307535200
*cite journal | author=Tatsumi Y, Ohta S, Kimura H, "et al." |title=The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1. |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 41528–34 |year= 2003 |pmid= 12909627 |doi= 10.1074/jbc.M307534200
*cite journal | author=Abdurashidova G, Danailov MB, Ochem A, "et al." |title=Localization of proteins bound to a replication origin of human DNA along the cell cycle. |journal=EMBO J. |volume=22 |issue= 16 |pages= 4294–303 |year= 2003 |pmid= 12912926 |doi= 10.1093/emboj/cdg404
*cite journal | author=Ramachandran N, Hainsworth E, Bhullar B, "et al." |title=Self-assembling protein microarrays. |journal=Science |volume=305 |issue= 5680 |pages= 86–90 |year= 2004 |pmid= 15232106 |doi= 10.1126/science.1097639
*cite journal | author=Lidonnici MR, Rossi R, Paixão S, "et al." |title=Subnuclear distribution of the largest subunit of the human origin recognition complex during the cell cycle. |journal=J. Cell. Sci. |volume=117 |issue= Pt 22 |pages= 5221–31 |year= 2005 |pmid= 15454574 |doi= 10.1242/jcs.01405

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