MCM3

MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), also known as MCM3, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.cite web | title = Entrez Gene: MCM3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4172| accessdate = ]

ee also

*Mini Chromosome Maintenance

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Thömmes P, Fett R, Schray B, "et al." |title=Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein. |journal=Nucleic Acids Res. |volume=20 |issue= 5 |pages= 1069–74 |year= 1992 |pmid= 1549468 |doi=
*cite journal | author=Musahl C, Schulte D, Burkhart R, Knippers R |title=A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins. |journal=Eur. J. Biochem. |volume=230 |issue= 3 |pages= 1096–101 |year= 1995 |pmid= 7601140 |doi=
*cite journal | author=Schulte D, Burkhart R, Musahl C, "et al." |title=Expression, phosphorylation and nuclear localization of the human P1 protein, a homologue of the yeast Mcm 3 replication protein. |journal=J. Cell. Sci. |volume=108 ( Pt 4) |issue= |pages= 1381–9 |year= 1995 |pmid= 7615659 |doi=
*cite journal | author=Starborg M, Brundell E, Gell K, "et al." |title=A murine replication protein accumulates temporarily in the heterochromatic regions of nuclei prior to initiation of DNA replication. |journal=J. Cell. Sci. |volume=108 ( Pt 3) |issue= |pages= 927–34 |year= 1995 |pmid= 7622621 |doi=
*cite journal | author=Burkhart R, Schulte D, Hu D, "et al." |title=Interactions of human nuclear proteins P1Mcm3 and P1Cdc46. |journal=Eur. J. Biochem. |volume=228 |issue= 2 |pages= 431–8 |year= 1995 |pmid= 7705359 |doi=
*cite journal | author=Kubota Y, Mimura S, Nishimoto S, "et al." |title=Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. |journal=Cell |volume=81 |issue= 4 |pages= 601–9 |year= 1995 |pmid= 7758114 |doi=
*cite journal | author=Madine MA, Khoo CY, Mills AD, Laskey RA |title=MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. |journal=Nature |volume=375 |issue= 6530 |pages= 421–4 |year= 1995 |pmid= 7760938 |doi= 10.1038/375421a0
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Hu B, Burkhart R, Schulte D, "et al." |title=The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. |journal=Nucleic Acids Res. |volume=21 |issue= 23 |pages= 5289–93 |year= 1994 |pmid= 8265339 |doi=
*cite journal | author=Schulte D, Richter A, Burkhart R, "et al." |title=Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins. |journal=Eur. J. Biochem. |volume=235 |issue= 1-2 |pages= 144–51 |year= 1996 |pmid= 8631321 |doi=
*cite journal | author=Ishimi Y, Ichinose S, Omori A, "et al." |title=Binding of human minichromosome maintenance proteins with histone H3. |journal=J. Biol. Chem. |volume=271 |issue= 39 |pages= 24115–22 |year= 1996 |pmid= 8798650 |doi=
*cite journal | author=Sato N, Arai K, Masai H |title=Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. |journal=EMBO J. |volume=16 |issue= 14 |pages= 4340–51 |year= 1997 |pmid= 9250678 |doi= 10.1093/emboj/16.14.4340
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Takei Y, Tsujimoto G |title=Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22177–80 |year= 1998 |pmid= 9712829 |doi=
*cite journal | author=Zhang JJ, Zhao Y, Chait BT, "et al." |title=Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. |journal=EMBO J. |volume=17 |issue= 23 |pages= 6963–71 |year= 1999 |pmid= 9843502 |doi= 10.1093/emboj/17.23.6963
*cite journal | author=Yankulov K, Todorov I, Romanowski P, "et al." |title=MCM proteins are associated with RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 6154–63 |year= 1999 |pmid= 10454562 |doi=
*cite journal | author=Fujita M, Yamada C, Goto H, "et al." |title=Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation. |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25927–32 |year= 1999 |pmid= 10464337 |doi=
*cite journal | author=Kuwahara K, Yoshida M, Kondo E, "et al." |title=A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication. |journal=Blood |volume=95 |issue= 7 |pages= 2321–8 |year= 2000 |pmid= 10733502 |doi=
*cite journal | author=Hofmann Y, Becker J, Wright F, "et al." |title=Genomic structure of the gene for the human P1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney disease. |journal=Eur. J. Hum. Genet. |volume=8 |issue= 3 |pages= 163–6 |year= 2000 |pmid= 10780780 |doi= 10.1038/sj.ejhg.5200426
*cite journal | author=Abe E, Kuwahara K, Yoshida M, "et al." |title=Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication. |journal=Gene |volume=255 |issue= 2 |pages= 219–27 |year= 2000 |pmid= 11024281 |doi=

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