MCM3AP

MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein, also known as MCM3AP, is a human gene.cite web | title = Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8888| accessdate = ]

PBB_Summary
section_title =
summary_text = The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is an MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.cite web | title = Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8888| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins "in vitro". |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=
*cite journal | author=Takei Y, Tsujimoto G |title=Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22177–80 |year= 1998 |pmid= 9712829 |doi=
*cite journal | author=Kuwahara K, Yoshida M, Kondo E, "et al." |title=A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication. |journal=Blood |volume=95 |issue= 7 |pages= 2321–8 |year= 2000 |pmid= 10733502 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Abe E, Kuwahara K, Yoshida M, "et al." |title=Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication. |journal=Gene |volume=255 |issue= 2 |pages= 219–27 |year= 2000 |pmid= 11024281 |doi=
*cite journal | author=Takei Y, Swietlik M, Tanoue A, "et al." |title=MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3. |journal=EMBO Rep. |volume=2 |issue= 2 |pages= 119–23 |year= 2001 |pmid= 11258703 |doi= 10.1093/embo-reports/kve026
*cite journal | author=Kuwahara K, Tomiyasu S, Fujimura S, "et al." |title=Germinal center-associated nuclear protein (GANP) has a phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regions. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 18 |pages= 10279–83 |year= 2001 |pmid= 11526238 |doi= 10.1073/pnas.181335698
*cite journal | author=EL-Gazzar MA, Maeda K, Nomiyama H, "et al." |title=PU.1 is involved in the regulation of B lineage-associated and developmental stage-dependent expression of the germinal center-associated DNA primase GANP. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48000–8 |year= 2002 |pmid= 11641399 |doi= 10.1074/jbc. M106696200
*cite journal | author=Kono Y, Maeda K, Kuwahara K, "et al." |title=MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR. |journal=Genes Cells |volume=7 |issue= 8 |pages= 821–34 |year= 2003 |pmid= 12167160 |doi=
*cite journal | author=Takei Y, Assenberg M, Tsujimoto G, Laskey R |title=The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43121–5 |year= 2003 |pmid= 12226073 |doi= 10.1074/jbc. C200442200
*cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sakaguchi N, Fujimura S, Kuwahara K |title=Involvement of GANP in B cell activation in T cell-dependent antigen response. |journal=Dev. Immunol. |volume=9 |issue= 3 |pages= 169–72 |year= 2003 |pmid= 12885157 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hu YH, Warnatz HJ, Vanhecke D, "et al." |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. |journal=BMC Genomics |volume=7 |issue= |pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155

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